Various diseases remain untreated due to lack of suitable therapeutic moiety or a suitable
drug delivery device, especially where toxicities and side effects are the primary reason for …

The oral mucosa's accessibility, excellent blood supply, by-pass of hepatic first-pass
metabolism, rapid repair and permeability profile make it an attractive site for local and …

The aim of this review paper is to compare the potential of various techniques developed for
production of homogenous, stable liposomes. Traditional techniques, such as Bangham …

Paclitaxel (Taxol) is a diterpenoid isolated from Taxus brevifolia, approved by the FDA for
the treatment of ovarian and breast cancers. Due to its low solubility in water, it is clinically …

Great expectations from the application of gene therapy approaches to human disease have
been impaired by the unsatisfactory clinical progress observed. Among others, the use of an …

Vesicles, generally defined as self-assembled structures formed by single or multiple
concentric bilayers that surround an aqueous core, have been widely used for biomedical …

Gene transfer represents an important advance in the treatment of both genetic and
acquired diseases. Many cationic lipids and cationic polymers naturally occurred or …

This review highlights the relevant issues of spontaneous formation of vesicles. Both the
common characteristics and the differences between liposomes and vesicles are given. The …

The taxanes, paclitaxel and docetaxel, are anticancer agents used in clinical trials against
ovarian carcinoma, breast, lung and head/neck cancer. Paclitaxel, very insoluble in water, is …

A novel liposomal formulation of paclitaxel targeting the folate receptor (FR) was
synthesized and characterized. This formulation was designed to overcome vehicle toxicity …