Opioid withdrawal: role in addiction and neural mechanisms
Withdrawal from opioids involves a negative affective state that promotes maintenance of
drug-seeking behavior and relapse. As such, understanding the neurobiological …
drug-seeking behavior and relapse. As such, understanding the neurobiological …
Endogenous opiates and behavior: 2014
RJ Bodnar - Peptides, 2016 - Elsevier
This paper is the thirty-seventh consecutive installment of the annual review of research
concerning the endogenous opioid system. It summarizes papers published during 2014 …
concerning the endogenous opioid system. It summarizes papers published during 2014 …
Similarities in alcohol and opioid withdrawal syndromes suggest common negative reinforcement mechanisms involving the interoceptive antireward pathway
SJ O'Sullivan, JS Schwaber - Neuroscience & Biobehavioral Reviews, 2021 - Elsevier
Alcohol and opioids are two major contributors to so-called deaths of despair. Though the
effects of these substances on mammalian systems are distinct, commonalities in their …
effects of these substances on mammalian systems are distinct, commonalities in their …
[HTML][HTML] The addicted brain: understanding the neurophysiological mechanisms of addictive disorders
The consumption of chemical substances that produce transient feelings of euphoria or
pleasure and the development of dependence on those substances by a subset of …
pleasure and the development of dependence on those substances by a subset of …
Molecular changes in opioid addiction: the role of adenylyl cyclase and cAMP/PKA system
P Chan, K Lutfy - Progress in molecular biology and translational …, 2016 - Elsevier
For centuries, opiate analgesics have had a considerable presence in the treatment of
moderate to severe pain. While effective in providing analgesia, opiates are notorious in …
moderate to severe pain. While effective in providing analgesia, opiates are notorious in …
[HTML][HTML] Self-administration of entactogen psychostimulants dysregulates gamma-aminobutyric acid (GABA) and kappa opioid receptor signaling in the central nucleus …
Male rats escalate intravenous self-administration of entactogen psychostimulants, 3, 4-
methylenedioxymethcathinone (methylone) and 3, 4-methylenedioxymethamphetamine …
methylenedioxymethcathinone (methylone) and 3, 4-methylenedioxymethamphetamine …
Effects of treadmill exercise and chronic stress on anxiety‐like behavior, neuronal activity, and oxidative stress in basolateral amygdala in morphine‐treated rats
The basolateral amygdala (BLA), which is sensitive to stress, is necessary for reward‐
seeking behavior and addiction. Regular exercise can produce various positive effects by …
seeking behavior and addiction. Regular exercise can produce various positive effects by …
[HTML][HTML] Differential effects of novel kappa opioid receptor antagonists on dopamine neurons using acute brain slice electrophysiology
Activation of the kappa opioid receptor (KOR) contributes to the aversive properties of stress,
and modulates key neuronal circuits underlying many neurobehavioral disorders. KOR …
and modulates key neuronal circuits underlying many neurobehavioral disorders. KOR …
[HTML][HTML] Repeated ketamine anesthesia during neurodevelopment upregulates hippocampal activity and enhances drug reward in male mice
Early exposures to anesthetics can cause long-lasting changes in excitatory/inhibitory
synaptic transmission (E/I imbalance), an important mechanism for neurodevelopmental …
synaptic transmission (E/I imbalance), an important mechanism for neurodevelopmental …
Contributions of the GABAergic system of the prelimbic cortex and basolateral amygdala to morphine withdrawal-induced contextual fear
FZ Seno, RF Sgobbi, MJ Nobre - Physiology & Behavior, 2022 - Elsevier
Morphine withdrawal can trigger disruptions in neuronal pathways involved in the
modulation and expression of anxiety and fear-related behaviors, particularly those involved …
modulation and expression of anxiety and fear-related behaviors, particularly those involved …