A forward vision for chemodynamic therapy: issues and opportunities
Since the insight to fuse Fenton chemistry and nanomedicine into cancer therapy, great
signs of progress have been made in the field of chemodynamic therapy (CDT). However …
signs of progress have been made in the field of chemodynamic therapy (CDT). However …
Doxorubicin—an agent with multiple mechanisms of anticancer activity
Doxorubicin (DOX) constitutes the major constituent of anti-cancer treatment regimens
currently in clinical use. However, the precise mechanisms of DOX's action are not fully …
currently in clinical use. However, the precise mechanisms of DOX's action are not fully …
Neuroprotective effect of antioxidants in the brain
KH Lee, M Cha, BH Lee - International journal of molecular sciences, 2020 - mdpi.com
The brain is vulnerable to excessive oxidative insults because of its abundant lipid content,
high energy requirements, and weak antioxidant capacity. Reactive oxygen species (ROS) …
high energy requirements, and weak antioxidant capacity. Reactive oxygen species (ROS) …
Endogenous photosensitizers in human skin
Endogenous photosensitizers play a critical role in both beneficial and harmful light-induced
transformations in biological systems. Understanding their mode of action is essential for …
transformations in biological systems. Understanding their mode of action is essential for …
Antioxidant enzymes regulation in plants in reference to reactive oxygen species (ROS) and reactive nitrogen species (RNS)
Reactive oxygen species (ROS) are generated in the plants during cellular metabolism. But
extreme environmental conditions like drought, salinity or floods etc. lead to an enhanced …
extreme environmental conditions like drought, salinity or floods etc. lead to an enhanced …
HIF-2α activation potentiates oxidative cell death in colorectal cancers by increasing cellular iron
Hypoxia is a hallmark of solid tumors that promotes cell growth, survival, and metastasis and
confers resistance to chemo and radiotherapies. Hypoxic responses are largely mediated by …
confers resistance to chemo and radiotherapies. Hypoxic responses are largely mediated by …
Carcinogens and DNA damage
JL Barnes, M Zubair, K John, MC Poirier… - Biochemical Society …, 2018 - portlandpress.com
Humans are variously and continuously exposed to a wide range of different DNA-damaging
agents, some of which are classed as carcinogens. DNA damage can arise from exposure to …
agents, some of which are classed as carcinogens. DNA damage can arise from exposure to …
[HTML][HTML] Sunlight damage to cellular DNA: Focus on oxidatively generated lesions
The routine and often unavoidable exposure to solar ultraviolet (UV) radiation makes it one
of the most significant environmental DNA-damaging agents to which humans are exposed …
of the most significant environmental DNA-damaging agents to which humans are exposed …
Mechanisms underlying the pathophysiology of type 2 diabetes: From risk factors to oxidative stress, metabolic dysfunction, and hyperglycemia
Abstract Type 2 diabetes (T2D) is a complex multifactorial disease that emerges from the
combination of genetic and environmental factors, and obesity, lifestyle, and aging are the …
combination of genetic and environmental factors, and obesity, lifestyle, and aging are the …
The biochemistry and effectiveness of antioxidants in food, fruits, and marine algae
It is more effective to maintain good health than to regain it after losing it. This work focuses
on the biochemical defense mechanisms against free radicals and their role in building and …
on the biochemical defense mechanisms against free radicals and their role in building and …