Introduction Neutrophil extracellular traps (NETs) are DNA scaffolds enriched with
antimicrobial proteins. NETs have been implicated in the development of various diseases …

Rationale: Infection with the SARS-CoV2 virus is associated with elevated neutrophil counts.
Evidence of neutrophil dysfunction in COVID-19 is based on transcriptomics or single …

Neutrophil dysfunction has been described with age, appears exaggerated in infection, with
altered phosphoinositol signaling a potential mechanism. However, functional aging is …

Vaccination, being able to prevent millions of cases of infectious diseases around the world
every year, is the most effective medical intervention ever introduced. However …

The neutrophil-to-lymphocyte ratio (NLR) is a trans-prognostic biomarker of physiologic
stress and inflammation linked to muscle weakness in older adults. Generation of grip force …

Acute respiratory distress syndrome (ARDS) is associated with increased morbidity and
mortality in the elderly population (≥ 65 years of age). Additionally, age is widely reported …

Sepsis is a form of life-threatening organ dysfunction caused by dysregulated host
responses to an infection that can be partly attributed to immune dysfunction. Although …

Age-related eye diseases, including dry eye, glaucoma, age-related macular degeneration,
and diabetic retinopathy, represent a major global health issue based on their increasing …

One of the most important determinants of aging-related changes is a complex biological
process emerged recently and called “immunosenescence”. Immunosenescence refers to …

Periodontitis is one of the most prevalent infectious inflammatory diseases, characterized by
irreversible destruction of the supporting tissues of teeth, which is correlated with a greater …