Neutrophils have been implicated in the pathogenesis of alpha-1 antitrypsin deficiency
(AATD) since the first descriptions of the disease. Neutrophil proteinases can cause all lung …

Purpose The aim of the paper is to establish and quantify the relation between healthy
ageing and the innate and adaptive immune parameters as indicators of age-related …

ANCA-associated vasculitis (AAV) is a severe systemic autoimmune disease. A key feature
of AAV is the presence of Anti-Neutrophil Cytoplasmic Antibodies (ANCA) directed against …

Aging negatively affects the endothelium. Endocan (ESM-1), an endothelium-derived
soluble proteoglycan, participates in fundamental biological processes of endothelial cells …

CD 4+ T cell subset imbalance plays an important role in the development of diabetic
complications. Neutrophils have recently been known as the regulator of CD 4+ T cell …

In their 1987 community-acquired pneumonia (CAP) guidelines, the British Thoracic Society
recommended amoxicillin with or without erythromycin (or tetracycline) in all admitted …

Sepsis is among the most important causes of mortality, particularly within the elderly
population. Sepsis prevalence is on the rise due to different factors, including increasing …

In the context of aging, the susceptibility to infectious diseases increases, leading to
heightened morbidity and mortality. This phenomenon, termed immunosenescence, is …

Immunization strategies for the elderly are frequently perceived as comprising only vaccines
against influenza, Streptococcus pneumoniae, and herpes zoster. However, besides these …

Rational Infection with the SARS-CoV2 virus is associated with elevated neutrophil counts.
Evidence of neutrophil dysfunction in COVID-19 is based predominantly on transcriptomics …