Remodelling of the immune system with age—immunosenescence—is a significant
contributor to poor health in older adults, with increasing risk of infections, cancer and …

The synthetic 2-cyano-3, 12-dioxo-oleana-1, 9 (11)-dien-28-oic acid methyl ester (CDDO-
Me) is a potent activator of the erythroid 2-p45-derived factor 2, Nrf2, a leucine-zipper …

Aging is associated with a progressive decline of the immune system function, that ultimately
results in an increased susceptibility to viral and bacterial infections. This phenomenon …

Chronic kidney disease (CKD) is associated with a high infective burden and poorer vaccine
responses. This thesis presents findings of a prospective observational study, where a non …

Aging remains a mysterious process, but age-associated changes in the different organ
systems constituting the whole organism are well known. One of the best studied both …

Studies in human aging mainly focus on αβ T cells while γδ T cells and skin-resident T cells
have been neglected despite their role in immunosurveillance. In this thesis, we showed that …

El notable incremento en la susceptibilidad del adulto mayor a infecciones se asocia a una
serie de alteraciones en las funciones efectoras de los neutrófilos polimorfonucleares …

Rheumatoid arthritis (RA) is an autoimmune disorder for which there is no known cause. The
disease is characterized by progressive joint destruction, mediated by breakdown of …

Immunosenescence is the alteration of the immune system due to aging process which
affects both innate and adaptive immunity. The major changes in innate immunity are …