Brain tumors

K Herholz, KJ Langen, C Schiepers… - Seminars in nuclear …, 2012 - Elsevier
This review addresses the specific contributions of nuclear medicine techniques, and
especially positron emission tomography (PET), for diagnosis and management of brain …

Imaging of amino acid transport in brain tumours: positron emission tomography with O-(2-[18F] fluoroethyl)-L-tyrosine (FET)

KJ Langen, G Stoffels, C Filss, A Heinzel, C Stegmayr… - Methods, 2017 - Elsevier
The assessment of cerebral gliomas using magnetic resonance imaging (MRI) provides
excellent structural images but cannot solve all diagnostic problems satisfactorily. The …

[18F]-fluoro-ethyl-l-tyrosine PET: a valuable diagnostic tool in neuro-oncology, but not all that glitters is glioma

M Hutterer, M Nowosielski, D Putzer, NL Jansen… - Neuro …, 2013 - academic.oup.com
Background To assess the sensitivity and specificity of [18F]-fluoro-ethyl-l-tyrosine (18F-FET)
PET in brain tumors and various non-neoplastic neurologic diseases. Methods We …

MRI-suspected low-grade glioma: is there a need to perform dynamic FET PET?

NL Jansen, V Graute, L Armbruster… - European journal of …, 2012 - Springer
Purpose Since differentiation between low-grade glioma (LGG) and high-grade glioma
(HGG) remains challenging according to MRI criteria alone, we investigated the …

Integrated boost IMRT with FET-PET-adapted local dose escalation in glioblastomas

MD Piroth, M Pinkawa, R Holy, J Klotz… - Strahlentherapie …, 2012 - search.proquest.com
Dose escalations above 60 Gy based on MRI have not led to prognostic benefits in
glioblastoma patients yet. With positron emission tomography (PET) using [^ sup 18^ F] …

Physical radiotherapy treatment planning based on functional PET/CT data

D Thorwarth, X Geets, M Paiusco - Radiotherapy and Oncology, 2010 - Elsevier
Positron emission tomography (PET) provides molecular information about the tumor
microenvironment in addition to anatomical imaging. Hence, it seems to be highly beneficial …

Amino-acid PET versus MRI guided re-irradiation in patients with recurrent glioblastoma multiforme (GLIAA)–protocol of a randomized phase II trial (NOA 10/ARO …

O Oehlke, M Mix, E Graf, T Schimek-Jasch, U Nestle… - BMC cancer, 2016 - Springer
Background The higher specificity of amino-acid positron emission tomography (AA-PET) in
the diagnosis of gliomas, as well as in the differentiation between recurrence and treatment …

Update on amino acid PET of brain tumours

KJ Langen, N Galldiks - Current opinion in neurology, 2018 - journals.lww.com
PET using radiolabelled amino acids is a rapidly evolving method that can significantly
enhance the diagnostic value of MRI in brain tumours. Current developments suggest that …

PET Imaging in glioblastoma: Use in clinical practice

A Verger, KJ Langen - Exon Publications, 2017 - exonpublications.com
Positron emission tomography (PET) is a nuclear medicine imaging method with increasing
relevance for the diagnosis, prognostication, and monitoring of glioblastomas. PET provides …

Integrated-boost IMRT or 3-D-CRT using FET-PET based auto-contoured target volume delineation for glioblastoma multiforme-a dosimetric comparison

MD Piroth, M Pinkawa, R Holy, G Stoffels, C Demirel… - Radiation …, 2009 - Springer
Background Biological brain tumor imaging using O-(2-[18 F] fluoroethyl)-L-tyrosine (FET)-
PET combined with inverse treatment planning for locally restricted dose escalation in …