[HTML][HTML] Nanotechnology based drug delivery systems for the treatment of anterior segment eye diseases

AL Onugwu, CS Nwagwu, OS Onugwu… - Journal of Controlled …, 2023 - Elsevier
Diseases affecting the anterior segment of the eye are the primary causes of vision
impairment and blindness globally. Drug administration through the topical ocular route is …

[HTML][HTML] Updates on the Diagnosis and Management of Glaucoma

IV Wagner, MW Stewart, SK Dorairaj - Mayo Clinic Proceedings …, 2022 - Elsevier
Glaucoma is the leading cause of blindness throughout the world (after cataracts); therefore,
general physicians should be familiar with the diagnosis and management of affected …

[HTML][HTML] Terrestrial health applications of visual assessment technology and machine learning in spaceflight associated neuro-ocular syndrome

J Ong, A Tavakkoli, N Zaman, SA Kamran… - npj …, 2022 - nature.com
The neuro-ocular effects of long-duration spaceflight have been termed Spaceflight
Associated Neuro-Ocular Syndrome (SANS) and are a potential challenge for future, human …

Aging, oxidative stress and degenerative diseases: mechanisms, complications and emerging therapeutic strategies

MR Chaudhary, S Chaudhary, Y Sharma, TA Singh… - Biogerontology, 2023 - Springer
Aging accompanied by several age-related complications, is a multifaceted inevitable
biological progression involving various genetic, environmental, and lifestyle factors. The …

[HTML][HTML] Cellular stress signaling and the unfolded protein response in retinal degeneration: mechanisms and therapeutic implications

T McLaughlin, A Medina, J Perkins, M Yera… - Molecular …, 2022 - Springer
Background The retina, as part of the central nervous system (CNS) with limited capacity for
self-reparation and regeneration in mammals, is under cumulative environmental stress due …

[HTML][HTML] Oxidative stress: a suitable therapeutic target for optic nerve diseases?

F Buonfiglio, EW Böhm, N Pfeiffer, A Gericke - Antioxidants, 2023 - mdpi.com
Optic nerve disorders encompass a wide spectrum of conditions characterized by the loss of
retinal ganglion cells (RGCs) and subsequent degeneration of the optic nerve. The etiology …

[HTML][HTML] The role of IL-6 in fibrotic diseases: molecular and cellular mechanisms

Y Li, J Zhao, Y Yin, K Li, C Zhang… - International journal of …, 2022 - ncbi.nlm.nih.gov
Fibrosis is a detrimental outcome of most chronic inflammatory disorders and is defined by
the buildup of excess extracellular matrix (ECM) components, which eventually leads to …

[HTML][HTML] Targeting the gut–eye axis: An emerging strategy to face ocular diseases

LIM Campagnoli, A Varesi, A Barbieri… - International Journal of …, 2023 - mdpi.com
The human microbiota refers to a large variety of microorganisms (bacteria, viruses, and
fungi) that live in different human body sites, including the gut, oral cavity, skin, and eyes. In …

[HTML][HTML] miRNA studies in glaucoma: a comprehensive review of current knowledge and future perspectives

M Dobrzycka, A Sulewska, P Biecek… - International Journal of …, 2023 - mdpi.com
Glaucoma, a neurodegenerative disorder that leads to irreversible blindness, remains a
challenge because of its complex nature. MicroRNAs (miRNAs) are crucial regulators of …

[HTML][HTML] Clinical pharmacology and pharmacogenetics of prostaglandin analogues in glaucoma

L Zhou, W Zhan, X Wei - Frontiers in Pharmacology, 2022 - frontiersin.org
Glaucoma is the main cause of irreversible visual loss worldwide, and comprises a group of
progressive, age-related, and chronic optic neuropathies. Prostaglandin analogs are …