Cancer vaccine therapeutics: limitations and effectiveness—A literature review

M Kaczmarek, J Poznańska, F Fechner, N Michalska… - Cells, 2023 - mdpi.com
In recent years, there has been a surge of interest in tumor microenvironment-associated
cancer vaccine therapies. These innovative treatments aim to activate and enhance the …

Mechanisms and challenges of nanocarriers as non-viral vectors of therapeutic genes for enhanced pulmonary delivery

H Wang, L Qin, X Zhang, J Guan, S Mao - Journal of Controlled Release, 2022 - Elsevier
With the rapid development of biopharmaceuticals and the outbreak of COVID-19, the world
has ushered in a frenzy to develop gene therapy. Therefore, therapeutic genes have …

CRISPR/Cas9 genome editing for tissue‐specific in vivo targeting: nanomaterials and translational perspective

DK Sahel, LK Vora, A Saraswat, S Sharma… - Advanced …, 2023 - Wiley Online Library
Clustered randomly interspaced short palindromic repeats (CRISPRs) and its associated
endonuclease protein, ie, Cas9, have been discovered as an immune system in bacteria …

Electrostatic Attractive Self‐Delivery of siRNA and Light‐Induced Self‐Escape for Synergistic Gene Therapy

Y Yang, H Ning, T Xia, J Du, W Sun, J Fan… - Advanced …, 2023 - Wiley Online Library
Small interfering RNA (siRNA) holds immense promise for suppressing gene expression
and treating various life‐threatening diseases, including cancer. However, efficient delivery …

Recent advances in nanotechnology approaches for non-viral gene therapy

Y Jiang, M Fan, Z Yang, X Liu, Z Xu, S Liu… - Biomaterials …, 2022 - pubs.rsc.org
Gene therapy has shown great potential in the treatment of many diseases by
downregulating the expression of certain genes. The development of gene vectors as a …

Chitosan in oral drug delivery formulations: A review

T Sangnim, D Dheer, N Jangra, K Huanbutta, V Puri… - Pharmaceutics, 2023 - mdpi.com
Nanoformulations have become increasingly useful as drug delivery technologies in recent
decades. As therapeutics, oral administration is the most common delivery method, although …

New advances in biomedical application of polymeric micelles

A Figueiras, C Domingues, I Jarak, AI Santos, A Parra… - Pharmaceutics, 2022 - mdpi.com
In the last decade, nanomedicine has arisen as an emergent area of medicine, which
studies nanometric systems, namely polymeric micelles (PMs), that increase the solubility …

Polymeric nanoparticles—Tools in a drug delivery system in selected cancer therapies

M Madej, N Kurowska, B Strzalka-Mrozik - Applied Sciences, 2022 - mdpi.com
The increase in cancer cases is undoubtedly affecting the development of new therapeutic
approaches. Polymeric nanoparticles are of great interest. Due to their relatively small size …

De novo designed peptides for cellular delivery and subcellular localisation

GG Rhys, JA Cross, WM Dawson… - Nature Chemical …, 2022 - nature.com
Increasingly, it is possible to design peptide and protein assemblies de novo from first
principles or computationally. This approach provides new routes to functional synthetic …

Applications of ultrasound-mediated drug delivery and gene therapy

J Sitta, CM Howard - International Journal of Molecular Sciences, 2021 - mdpi.com
Gene therapy has continuously evolved throughout the years since its first proposal to
develop more specific and effective transfection, capable of treating a myriad of health …