The degree of binding to plasma proteins is an important determinant of drug disposition
and response. Normal human pregnancy is associated with considerable changes in the …

A drug displacement interaction is loosely defined as the reduction in extent of plasma
protein binding of one drug caused by the presence of another drug. These interactions may …

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The serum protein binding of valproate (di-n-propylacetate) has been determined at
therapeutic concentrations by equilibrium dialysis in man (94.8%), dog (78.5%), rat (63.4%) …

Objective Cardiopulmonary bypass is known to result in a reduction in the plasma binding of
drugs. The resulting effect on the hepatic clearance of drugs with low extraction is well …

Various nutritional and environmental factors are known to alter the rates at which drugs are
absorbed, distributed, metabolized, and eliminated from the body. Some of these factors …

The effects of route of administration and blood flow on the elimination of lidocaine,
diphenylhydantoin and propranolol have been investigated in the isolated perfused rat liver …

1. Quinidine is a potent inhibitor of the genetically‐determined debrisoquine 4‐
hydroxylation. Oxidation reactions of several other drugs, including the 5‐hydroxylation of …

The plasma binding of quinidine and phenytoin has been studied pre-and postoperatively in
nine patients submitted to planned gastric surgery. The binding of phenytoin showed a slight …

On the basis of well documented biochemical and pharmacological data about the influence
of drug mediated enzyme induction on the biotransformation of natural and synthetic sex …