[HTML][HTML] Metabolism and function of polyamines in cancer progression

IN Sari, T Setiawan, KS Kim, YT Wijaya, KW Cho… - Cancer Letters, 2021 - Elsevier
Polyamines are essential for the proliferation, differentiation, and development of
eukaryotes. They include spermine, spermidine, and the diamine precursor putrescine, and …

The role of metabolic plasticity of tumor-associated macrophages in shaping the tumor microenvironment immunity

MN Hasan, O Capuk, SM Patel, D Sun - Cancers, 2022 - mdpi.com
Simple Summary Tumor associated macrophages (TAMs) support disease progression by
providing tumor cells cytokines and chemokines necessary for malignant growth and …

[PDF][PDF] Multi-omics analysis reveals the chemoresistance mechanism of proliferating tissue-resident macrophages in PDAC via metabolic adaptation

J Zhang, J Song, S Tang, Y Zhao, L Wang, Y Luo… - Cell Reports, 2023 - cell.com
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer that typically
demonstrates resistance to chemotherapy. Tumor-associated macrophages (TAMs) are …

HIF: a master regulator of nutrient availability and metabolic cross‐talk in the tumor microenvironment

R Missiaen, NP Lesner, MC Simon - The EMBO journal, 2023 - embopress.org
A role for hypoxia‐inducible factors (HIFs) in hypoxia‐dependent regulation of tumor cell
metabolism has been thoroughly investigated and covered in reviews. However, there is …

Epigenetic reprogramming-induced guanidinoacetic acid synthesis promotes pancreatic cancer metastasis and transcription-activating histone modifications

J Yang, B Ren, J Ren, G Yang, Y Fang, X Wang… - Journal of Experimental …, 2023 - Springer
Background Pancreatic ductal adenocarcinoma (PDAC) tends to undergo distant
metastasis, especially liver metastasis, leading to a poor prognosis. Metabolic remodelling …

[HTML][HTML] Mitochondrial and metabolic alterations in cancer cells

J Di Gregorio, S Petricca, R Iorio, E Toniato… - European journal of cell …, 2022 - Elsevier
Metabolic alterations have been observed in many cancer types. The deregulated
metabolism has thus become an emerging hallmark of the disease, where the metabolism is …

Arginine depriving enzymes: applications as emerging therapeutics in cancer treatment

N Kumari, S Bansal - Cancer Chemotherapy and Pharmacology, 2021 - Springer
Cancer is the second leading cause of death globally. Chemotherapy and radiation therapy
and other medications are employed to treat various types of cancer. However, each …

Endosymbionts Reduce Microbiome Diversity and Modify Host Metabolism and Fecundity in the Planthopper Sogatella furcifera

TP Li, CY Zhou, MK Wang, SS Zha, J Chen, XL Bing… - Msystems, 2022 - Am Soc Microbiol
Endosymbionts can strongly affect bacterial microbiota in pests. The white-backed
planthopper Sogatella furcifera, a notorious pest in rice, is usually co-infected with …

The metabolism reprogramming of microRNA Let-7-mediated glycolysis contributes to autophagy and tumor progression

CH Li, CC Liao - International Journal of Molecular Sciences, 2021 - mdpi.com
Cancer is usually a result of abnormal glucose uptake and imbalanced nutrient
metabolization. The dysregulation of glucose metabolism, which controls the processes of …

Free amino acid alterations in patients with gynecological and breast cancer: a review

D Pietkiewicz, A Klupczynska-Gabryszak, S Plewa… - Pharmaceuticals, 2021 - mdpi.com
Gynecological and breast cancers still remain a significant health problem worldwide.
Diagnostic methods are not sensitive and specific enough to detect the disease at an early …