Sumoylation is an essential post-translational modification that has evolved to regulate
intricate networks within emerging complexities of eukaryotic cells. Thousands of target …

The concept of oxidative distress had arisen from the assessment of cellular response to
high concentrations of reactive species that result from an imbalance between oxidants and …

Mitochondria are the powerhouses of cells, responsible for energy production and
regulation of cellular homeostasis. When mitochondrial function is impaired, a stress …

If mitochondria are the powerhouses of the cell, then mitochondrial dynamics are the power
grid that regulates how that energy output is directed and maintained in response to unique …

Multiple Mitochondrial Dysfunctions Syndrome 1 (MMDS1) is a rare, autosomal recessive
disorder caused by mutations in the NFU1 gene. NFU1 is responsible for delivery of iron …

Protein homeostasis (proteostasis) is maintained by a tightly regulated and interconnected
network of biological pathways, preventing the accumulation and aggregation of damaged …

Calorie restriction (CR) provides anti-aging benefits through diverse processes, such as
reduced metabolism and growth and increased mitochondrial activity. Although controversy …

SUMOylation, a conserved protein post-translational modification that performs multiple
functions including regulation of nuclear transport and transcription, is implicated in …

Ageing is a biological process guided by genetic and environmental factors that ultimately
lead to adverse outcomes for organismal lifespan and healthspan. Determination of …

This dissertation is about the development of gene expression signature (GES) search
methods and their application in drug discovery, specifically for promoting healthy aging …