Alzheimer's disease (AD) is the most common cause of dementia worldwide, and its
prevalence is rapidly increasing due to extended lifespans. Among the increasing number of …

Liver X receptors α and β (LXRα and LXRβ) are nuclear receptors with pivotal roles in the
transcriptional control of lipid metabolism. Transcriptional activity of LXRs is induced in …

The tumor microenvironment (TME) in gastric cancer (GC) has been shown to be important
for tumor control but the specific characteristics for GC are not fully appreciated. We …

Oxidized phospholipids (OxPL) are ubiquitous, are formed in many inflammatory tissues,
including atherosclerotic lesions, and frequently mediate proinflammatory changes …

Apolipoprotein E (APOE) is a strong genetic risk factor for late-onset Alzheimer's disease
(LOAD). APOE4 increases and APOE2 decreases risk relative to APOE3. In the P301S …

Distinct macrophage populations throughout the body display highly heterogeneous
transcriptional and epigenetic programs. Recent research has highlighted that these profiles …

Hypercholesterolaemia leads to cholesterol accumulation in macrophages and other
immune cells, which promotes inflammatory responses, including augmentation of Toll-like …

APOE4 is the greatest genetic risk factor for late-onset Alzheimer's disease (AD), increasing
the risk of developing the disease by 3-fold in the 14% of the population that are carriers …

The liver X receptors (LXRs) are pivotal regulators of lipid homeostasis in mammals. These
transcription factors control the expression of a battery of genes involved in the uptake …

The human gut is colonized with a wide variety of microorganisms, including species, such
as those belonging to the bacterial genus Bifidobacterium, that have beneficial effects on …