[HTML][HTML] Genome regulation by polycomb and trithorax: 70 years and counting
B Schuettengruber, HM Bourbon, L Di Croce, G Cavalli - Cell, 2017 - cell.com
Polycomb (PcG) and Trithorax (TrxG) group proteins are evolutionarily conserved chromatin-
modifying factors originally identified as part of an epigenetic cellular memory system that …
modifying factors originally identified as part of an epigenetic cellular memory system that …
Histone exchange, chromatin structure and the regulation of transcription
S Venkatesh, JL Workman - Nature reviews Molecular cell biology, 2015 - nature.com
The packaging of DNA into strings of nucleosomes is one of the features that allows
eukaryotic cells to tightly regulate gene expression. The ordered disassembly of …
eukaryotic cells to tightly regulate gene expression. The ordered disassembly of …
Temporally distinct post-replicative repair mechanisms fill PRIMPOL-dependent ssDNA gaps in human cells
PRIMPOL repriming allows DNA replication to skip DNA lesions, leading to ssDNA gaps.
These gaps must be filled to preserve genome stability. Using a DNA fiber approach to …
These gaps must be filled to preserve genome stability. Using a DNA fiber approach to …
Hijacked in cancer: the KMT2 (MLL) family of methyltransferases
Abstract Histone–lysine N-methyltransferase 2 (KMT2) family proteins methylate lysine 4 on
the histone H3 tail at important regulatory regions in the genome and thereby impart crucial …
the histone H3 tail at important regulatory regions in the genome and thereby impart crucial …
Disruption of KMT2D perturbs germinal center B cell development and promotes lymphomagenesis
J Zhang, D Dominguez-Sola, S Hussein, JE Lee… - Nature medicine, 2015 - nature.com
Mutations in the gene encoding the KMT2D (or MLL2) methyltransferase are highly recurrent
and occur early during tumorigenesis in diffuse large B cell lymphoma (DLBCL) and …
and occur early during tumorigenesis in diffuse large B cell lymphoma (DLBCL) and …
Transcriptional regulation by Polycomb group proteins
L Di Croce, K Helin - Nature structural & molecular biology, 2013 - nature.com
Polycomb group (PcG) proteins are epigenetic regulators of transcription that have key roles
in stem-cell identity, differentiation and disease. Mechanistically, they function within …
in stem-cell identity, differentiation and disease. Mechanistically, they function within …
PRC2 is high maintenance
As the process that silences gene expression ensues during development, the stage is set
for the activity of Polycomb-repressive complex 2 (PRC2) to maintain these repressed gene …
for the activity of Polycomb-repressive complex 2 (PRC2) to maintain these repressed gene …
Regulation of nucleosome dynamics by histone modifications
GE Zentner, S Henikoff - Nature structural & molecular biology, 2013 - nature.com
Chromatin is a dynamic structure that must respond to myriad stimuli to regulate access to
DNA, and chemical modification of histones is a major means by which the cell modulates …
DNA, and chemical modification of histones is a major means by which the cell modulates …
[HTML][HTML] Interplay between the cancer genome and epigenome
Cancer arises as a consequence of cumulative disruptions to cellular growth control with
Darwinian selection for those heritable changes that provide the greatest clonal advantage …
Darwinian selection for those heritable changes that provide the greatest clonal advantage …
Chromatin modifiers and remodellers: regulators of cellular differentiation
T Chen, SYR Dent - Nature Reviews Genetics, 2014 - nature.com
Cellular differentiation is, by definition, epigenetic. Genome-wide profiling of pluripotent cells
and differentiated cells suggests global chromatin remodelling during differentiation, which …
and differentiated cells suggests global chromatin remodelling during differentiation, which …