Neurons of the mammalian central nervous system fail to regenerate. Substantial progress
has been made toward identifying the cellular and molecular mechanisms that underlie …

As the nervous system develops, newly differentiated neurons need to extend their axons
toward their synaptic targets to form functional neural circuits. During this highly dynamic …

Drug resistance and cancer relapse represent significant therapeutic challenges after
chemotherapy or immunotherapy, and a major limiting factor for long-term cancer survival …

Understanding spinal cord assembly is essential to elucidate how motor behavior is
controlled and how disorders arise. The human spinal cord is exquisitely organized, and this …

The mammalian cerebral cortex is the pinnacle of brain evolution, reaching its maximum
complexity in terms of neuron number, diversity and functional circuitry. The emergence of …

Spinal cord injury (SCI) results in massive neuronal death, axonal disruption, and cascading
inflammatory response, which causes further damage to impaired neurons. The survived …

The cerebral cortex varies dramatically in size and complexity between amniotes due to
differences in neuron number and composition. These differences emerge during embryonic …

Mechanical replacement prosthetics have advanced in both esthetics and mechanical
functions, but still require progress in attaining full natural functionality via tactile feedback …

Functional recovery following incomplete spinal cord injury (SCI) depends on the rewiring of
motor circuits during which supraspinal connections form new contacts onto spinal relay …

The c-Jun NH2-terminal protein kinase (JNK) is a Janus-faced kinase, which, in the nervous
system, plays important roles in a broad range of physiological and pathological processes …