The dissolution, intestinal absorption and presystemic metabolism of a drug depend on its
physicochemical characteristics but also on numerous physiological (eg gastrointestinal pH …

Background: The incidence of hemodynamically significant patent ductus arteriosus
(hsPDA) increases with decreasing gestational age and is associated with many common …

Traditional pharmacotherapy suffers from multiple drawbacks that hamper patient treatment,
such as the buildup of antibiotic resistances or low drug selectivity and toxicity during …

Objective To determine the incidence of acute kidney injury (AKI) in infants exposed to
nephrotoxic drug combinations admitted to 268 neonatal intensive care units managed by …

Calcium is a key ion involved in cardiac and skeletal muscle contractility, nerve function, and
skeletal structure. Global calcium balance is affected by parathyroid hormone and vitamin D …

Background: Very preterm birth often results in the development of bronchopulmonary
dysplasia (BPD) with an inverse correlation of gestational age and birthweight. This very …

A patent ductus arteriosus (PDA) in infants born premature can present significant
management challenges for neonatal providers. Quantifying a hemodynamically significant …

Only a small fraction of drugs widely used in neonatal intensive care units (NICU) are
specifically authorized for this population. Even if unlicensed or off-label use is necessary, it …

The association between the patent ductus arteriosus (PDA) and neonatal morbidity,
mortality and poor neurodevelopmental outcome in later childhood has been the focus of …

Background Transient tachypnoea of the newborn (TTN) is characterised by tachypnoea
and signs of respiratory distress. It is caused by delayed clearance of lung fluid at birth. TTN …