The Trk receptors and their neurotrophin ligands control development and maintenance of
the nervous system. The crystal structures of the ligand binding domain of TrkA, TrkB, and …

Chronic pain presents a huge economic and social burden, with existing treatments largely
unable to satisfy medical needs. Recently, studies have shown that nerve growth factor …

Target-derived neurotrophin nerve growth factor (NGF) and its receptor TrkA are well known
for retrograde signaling to promote survival and innervation of sympathetic and sensory …

The generation of biologically active proteins by regulated intramembrane proteolysis is a
highly conserved mechanism in cell signaling. Presenilin-dependent γ-secretase activity is …

Plexins represent a novel family of transmembrane receptors that transduce attractive and
repulsive signals mediated by the axon-guiding molecules semaphorins. Emerging …

Toward understanding topographically specific branching of retinal axons in their target
area, we have studied the interaction between neurotrophin receptors and members of the …

We have generated null mutant mice that lack expression of all isoforms encoded by the trkC
locus. These mice display a behavioral phenotype characterized by a loss of proprioceptive …

The Trk family of neurotrophin receptors, which includes the three highly homologous
proteins TrkA, TrkB and TrkC, is strongly associated with central and peripheral nervous …

MuSK is a receptor tyrosine kinase expressed selectively in skeletal muscle and localized to
neuromuscular synapses. Agrin activates MuSK and stimulates phosphorylation and …

Connective tissue growth factor (CTGF) is implicated as a factor promoting tissue fibrosis in
several disorders, including diabetic nephropathy. However, the molecular mechanism (s) …