Neurotrophin receptor structure and interactions
H Yano, MV Chao - Pharmaceutica Acta Helvetiae, 2000 - Elsevier
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A splice variant of the neurotrophin receptor trkB with increased specificity for brain‐derived neurotrophic factor.
The trkB gene codes for a receptor tyrosine kinase, which is essential for the development of
the peripheral nervous system. This receptor can be activated by three different …
the peripheral nervous system. This receptor can be activated by three different …
A designed peptidomimetic agonistic ligand of TrkA nerve growth factor receptors
S Maliartchouk, Y Feng, L Ivanisevic, T Debeir… - Molecular …, 2000 - ASPET
A proteolytically stable small molecule β-turn peptidomimetic, termed D3, was identified as
an agonist of the TrkA neurotrophin receptor. D3 binds the Ig-like C2 region of the …
an agonist of the TrkA neurotrophin receptor. D3 binds the Ig-like C2 region of the …
Specificity in Trk receptor: neurotrophin interactions: the crystal structure of TrkB-d5 in complex with neurotrophin-4/5
MJ Banfield, RL Naylor, AGS Robertson, SJ Allen… - Structure, 2001 - cell.com
Background: The binding of neurotrophin ligands to their respective Trk cellular receptors
initiates intracellular signals essential for the growth and survival of neurons. The site of …
initiates intracellular signals essential for the growth and survival of neurons. The site of …
An agonistic TrkB mAb causes sustained TrkB activation, delays RGC death, and protects the retinal structure in optic nerve axotomy and in glaucoma
Y Bai, J Xu, F Brahimi, Y Zhuo… - … & visual science, 2010 - iovs.arvojournals.org
Purpose.: Brain-derived neurotrophic factor (BDNF) receptors TrkB and p75 NTR are
expressed in the retina. However, exogenous BDNF does not provide retinal ganglion cells …
expressed in the retina. However, exogenous BDNF does not provide retinal ganglion cells …
TrkA immunoglobulin-like ligand binding domains inhibit spontaneous activation of the receptor
JC Arevalo, B Conde, BL Hempstead… - … and cellular biology, 2000 - Taylor & Francis
The extracellular region of the nerve growth factor (NGF) receptor, TrkA, contains two
immunoglobulin (Ig)-like domains that are required for specific ligand binding. We have …
immunoglobulin (Ig)-like domains that are required for specific ligand binding. We have …
GM1 ganglioside induces phosphorylation and activation of Trk and Erk in brain
AM Duchemin, Q Ren, L Mo, NH Neff… - Journal of …, 2002 - Wiley Online Library
We investigated the ability of GM1 to induce phosphorylation of the tyrosine kinase receptor
for neurotrophins, Trk, in rat brain, and activation of possible down‐stream signaling …
for neurotrophins, Trk, in rat brain, and activation of possible down‐stream signaling …
Receptor binding, internalization, and retrograde transport of neurotrophic factors
KE Neet, RB Campenot - Cellular and Molecular Life Sciences CMLS, 2001 - Springer
This review deals with the receptor interactions of neurotrophic factors, focusing on the
neurotrophins of the nerve growth factor (NGF) family, the glial cell derived neurotrophic …
neurotrophins of the nerve growth factor (NGF) family, the glial cell derived neurotrophic …
Distinct subdomains of the EphA3 receptor mediate ligand binding and receptor dimerization
Eph receptor tyrosine kinases and their ligands (ephrins) are highly conserved protein
families implicated in patterning events during development, particularly in the nervous …
families implicated in patterning events during development, particularly in the nervous …
Time course and nerve growth factor dependence of inflammation-induced alterations in electrophysiological membrane properties in nociceptive primary afferent …
L Djouhri, D Dawbarn, A Robertson… - Journal of …, 2001 - Soc Neuroscience
Novel findings of changes in nociceptive dorsal root ganglion (DRG) neurons during
hindlimb inflammation induced by complete Freund9s adjuvant (CFA) injections in the …
hindlimb inflammation induced by complete Freund9s adjuvant (CFA) injections in the …