Neurotrophins are important for the development and maintenance of the vertebrate nervous
system, mediating their signal into the cell by specific interaction with tyrosine kinase …

The monoclonal antibody MNAC13 is a potent antagonist that prevents the binding of nerve-
growth factor (NGF) to its tyrosine kinase A receptor (TrkA) in a variety of systems. Structural …

Neurotrophins and their receptors (Trk) play key roles in the development of the nervous
system and in cell survival. Trk receptors are therefore attractive pharmacological targets for …

Neuroblastoma (NB) isanembryonictumourthatoriginatesfromcell… (NC) arrested in their
differentiation at different stages along the sympatho-adrenal lineage and, less frequently …

Nerve growth factor (NGF) initiates its biological effects by promoting the dimerization and
activation of the tyrosine kinase receptor TrkA. The requirements for NGF signaling through …

This article presents experimental evidence and computed molecular models of a potential
interaction between receptor domain D5 of TrkB with the carboxyl-terminal domain of …

Neurotrophin 3 (NT-3) plays an important role in the development of the nervous system as
well as in mediating the survival of neurons in the adult nervous system. NT-3 functions by …

The Trk family is composed of three principal members (A, B and C), also termed
neurotrophin tyrosine kinase receptors (NTRK1, NTRK2, NTRK3), with several additional …

O processo de nocicepção pode ser caracterizado como uma sensação que é capturada e
transmitida por neurônios periféricos (nociceptores), sensação esta que pode se originar de …

A series of mutants with deletion in the extracellular portion of TrkB were expressed
transiently and stably in mammalian cells to examine the brain-derived neurotrophic factor …