Nucleic acid sensors, primarily TLR and RLR family members, as well as cGAS–STING
signalling, play a critical role in the preservation of cellular and organismal homeostasis …

Chemical modification of transcripts with 5′ caps occurs in all organisms. Here, we report a
systems-level mass spectrometry-based technique, CapQuant, for quantitative analysis of an …

Amphibian skin is a mucosal surface in direct and continuous contact with a microbially
diverse and laden aquatic and/or terrestrial environment. As such, frog skin is an important …

The COVID‐19 pandemic caused relatively high mortality in patients, especially in those
with concomitant diseases (ie, diabetes, hypertension, and chronic obstructive pulmonary …

Background Chronic rhinosinusitis (CRS) without nasal polyps (CRSsNP) is a common
disease that is characterized by multiple inflammatory endotypes. However, the molecular …

Innate immunity and the actions of type I and III interferons (IFNs) are essential for protection
from SARS-CoV-2 and COVID-19. Each is induced in response to infection and serves to …

The current dogma of RNA-mediated innate immunity is that sensing of immunostimulatory
RNA ligands is sufficient for the activation of intracellular sensors and induction of interferon …

The infection of mammalian cells by viruses and innate immune responses to infection are
spatiotemporally organized processes. Cytosolic RNA sensors trigger nuclear translocation …

Skin injuries and chronic non-healing wounds are one of the major global burdens on the
healthcare systems worldwide due to their difficult-to-treat nature, associated co-morbidities …

Two messenger RNA (mRNA) vaccines developed by Pfizer‐BioNTech and Moderna are
being rolled out. Despite the high volume of emerging evidence regarding adverse events …