Summary Type I interferons (IFN-I) are essential to establish antiviral innate immunity.
Unanchored (or free) polyubiquitin (poly-Ub) has been shown to regulate IFN-I responses …

Swine enteric coronavirus (SeCoV) causes acute gastroenteritis and high mortality in
newborn piglets. Since the last century, porcine transmissible gastroenteritis virus (TGEV) …

Ligands targeting nucleic acid-sensing receptors activate the innate immune system and
play a critical role in antiviral and antitumoral therapy. However, ligand design for in situ …

Influenza virus infection triggers host innate immune response by stimulating various pattern
recognition receptors (PRRs). Activation of these PRRs leads to the activation of a plethora …

Inflammatory signaling is required for hematopoietic stem and progenitor cell (HSPC)
development. Here, we studied the involvement of RIG-I-like receptors (RLRs) in HSPC …

The coronavirus disease 2019 (COVID-19) pandemic continues to burden healthcare
systems worldwide. COVID-19 symptoms are highly heterogeneous, and the patient may be …

The immune system plays an indispensable role in maintaining human health against the
invasion of foreign materials, microorgainisms and pathogens. The autoimmune diseases …

EGFR inhibition is an effective treatment in the minority of non-small cell lung cancer
(NSCLC) cases harboring EGFR-activating mutations, but not in EGFR wild-type (EGFRwt) …

Multi-functional DEAD-box helicase 5 (DDX5), which is important in transcriptional
regulation, is hijacked by diverse viruses to facilitate viral replication. However, its regulatory …

Zoonotic infections are an imminent threat to human health. Pangolins were recently
identified as carriers and intermediate hosts of coronaviruses. Previous research has shown …