Dysregulated immune response is the key factor leading to unfavorable coronavirus disease
2019 (COVID-19) outcome. Depending on the pathogen-associated molecular pattern, the …

The Golgi apparatus serves as a receiving station where proteins from the endoplasmic
reticulum (ER) are further processed before being sent to other cellular compartments. In …

The intracellular protozoan parasite Toxoplasma gondii is capable of infecting most
nucleated cells, where it survives in a specially modified compartment called the …

ABSTRACT TBK1 (TANK binding kinase 1) is an essential kinase of antiviral immunity, yet
the regulatory mechanisms responsible for its stringent control via autophagy are not fully …

Astrocytes are the most numerous cell type in the brain and perform several essential
functions in supporting neuronal metabolism and actively participating in neural circuit and …

Coronaviruses express a papain-like protease (PLpro) that is required for replicase
polyprotein maturation and also serves as a deubiquitinating enzyme (DUB). In this study …

IFN regulatory factor (IRF) 3 has been identified as the most critical regulator of both RNA
and DNA virus–induced IFN production in mammals. However, ambiguity exists in research …

Background There is scarce information on the human immune response to the SARS-CoV-
2 infection, and on the exacerbated inflammatory reaction observed in severe COVID-19 …

Severe fever with thrombocytopenia syndrome (SFTS) has been acknowledged as an
emerging infectious disease that is caused by the SFTS virus (SFTSV). The main clinical …

Advances in molecular biology have revolutionized the use of messenger RNA (mRNA) as a
therapeutic. The concept of nucleic acid therapy with mRNA originated in 1990 when Wolff …