Alcohol is one of the most widely consumed psychoactive drugs globally. Hazardous
drinking, defined by quantity and frequency of consumption, is associated with acute and …

Alcohol use disorders consist of disorders characterised by compulsive heavy alcohol use
and loss of control over alcohol intake. Alcohol use disorders are some of the most prevalent …

Critical features of human addiction are increasingly being incorporated into complementary
animal models, including escalation of drug intake, punished drug seeking and taking …

In the past decades, reductionism has dominated both research directions and funding
policies in clinical psychology and psychiatry. The intense search for the biological basis of …

Ethanol is one of the most commonly abused drugs. Although environmental and genetic
factors contribute to the etiology of alcohol use disorders, it is ethanol's actions in the brain …

In recent years, animal models in psychiatric research have been criticized for their limited
translational value to the clinical situation. Failures in clinical trials have thus often been …

Alcohol addiction leads to increased choice of alcohol over healthy rewards. We established
an exclusive choice procedure in which~ 15% of outbred rats chose alcohol over a high …

Alcohol-dependent patients commonly show impairments in executive functions that
facilitate craving and can lead to relapse. However, the molecular mechanisms leading to …

Compulsive drinking despite serious adverse medical, social and economic consequences
is a characteristic of alcohol use disorders in humans. Although frontal cortical areas have …

Our tendency to see the world of psychiatric illness in dichotomous and opposing terms has
three major sources: the philosophy of Descartes, the state of neuropathology in late …