Mammalian carboxylesterases (CEs) are key enzymes from the serine hydrolase
superfamily. In the human body, two predominant carboxylesterases (CES1 and CES2) …

Introduction: Carboxylesterases play major roles in the hydrolysis of numerous
therapeutically active compounds. This is, in part, due to the prevalence of the ester moiety …

Over the years, significant progress has been made in reducing metabolic instability due to
cytochrome P450-mediated oxidation. High-throughput metabolic stability screening has …

Mammalian carboxylesterases (CEs) are important serine hydrolases catalyzing the
hydrolysis of ester-or amide-containing compounds into the corresponding alcohols and …

Carboxylesterases (CES) have important roles in pesticide and drug metabolism and
contribute to the clearance of ester-containing xenobiotics in mammals. Tissues with the …

Aim: To identify the critical chemical features, with reliable geometric constraints, that
contributes to the inhibition of butyrylcholinesterase (BChE) function. Methods: Ligand …

The roots of Salvia miltiorrhiza (“Danshen”) are used in traditional Chinese medicine for the
treatment of numerous ailments including cardiovascular disease, hypertension, and …

An expanded series of alkyl 2-arylhydrazinylidene-3-oxo-3-polyfluoroalkylpropionates
(HOPs) 3 was obtained via Cu (OAc) 2-catalyzed azo coupling. All were nanomolar …

Photopolymerization of (meth) acrylate-based formulations has become a widespread
method for industry due to the high energy efficiency and low curing times of this technology …

CPT-11 is an antitumor prodrug that is hydrolyzed by carboxylesterases (CE) to yield SN-38,
a potent topoisomerase I poison. However, the dose limiting toxicity delays diarrhea that is …