Background The use of antithrombotic agents, including anticoagulants, antiplatelet agents,
and thrombolytics has increased over the last decade and is expected to continue to rise …

Objective Grading of recommendations, assessment, development, and evaluations
(GRADE) is arguably the most widely used method for appraising studies to be included in …

The Society for Vascular Surgery (SVS) and the American Venous Forum (AVF) have
developed clinical practice guidelines for the care of patients with varicose veins of the lower …

Background: Deep vein thrombosis (DVT) is the formation of blood clots (thrombi) in the
deep veins. It commonly affects the deep leg veins (such as the calf veins, femoral vein, or …

Background To develop the Antithrombotic Therapy and Prevention of Thrombosis, 9th ed:
ACCP Evidence-Based Clinical Practice Guidelines (AT9), the American College of Chest …

HIV infection has been recognized as a prothrombotic condition and this association has
now been proven by a large number of studies with a reported VTE frequency among HIV …

Observational studies have shown that inflammatory cells accumulate within the thrombus
and surrounding vein wall during the natural history of venous thrombosis. More recent …

The most important adverse effect of antithrombotic treatment is the occurrence of bleeding.
In the case of severe bleeding in a patient who uses anticoagulant agents or when a patient …

Thrombophilia, which severely impacts on morbidity and mortality of polycythaemia vera and
essential thrombocythaemia, is variably characterized by microcirculatory disturbances …

Cardiovascular disease is the leading cause of death around the world, in which myocardial
infarction (MI) is a precipitating event. However, current therapies do not adequately address …