Applications and advancements of nanoparticle-based drug delivery in alleviating lung cancer and chronic obstructive pulmonary disease

G De Rubis, KR Paudel, L Corrie, S Mehndiratta… - Naunyn-Schmiedeberg's …, 2024 - Springer
Lung cancer (LC) and chronic obstructive pulmonary disease (COPD) are among the
leading causes of mortality worldwide. Cigarette smoking is among the main aetiologic …

Nanomedicine combats drug resistance in lung cancer

X Zheng, X Song, G Zhu, D Pan, H Li, J Hu… - Advanced …, 2024 - Wiley Online Library
Lung cancer is the second most prevalent cancer and the leading cause of cancer‐related
death worldwide. Surgery, chemotherapy, molecular targeted therapy, immunotherapy, and …

Non‐Pore Dependent and MMP‐9 Responsive Gelatin/Silk Fibroin Composite Microparticles as Universal Delivery Platform for Inhaled Treatment of Lung Cancer

S Gou, G Wang, Y Zou, W Geng, T He, Z Qin… - Advanced …, 2023 - Wiley Online Library
Developing a drug delivery platform that possesses universal drug loading capacity to meet
various requirements of cancer treatment is a challenging yet interesting task. Herein, a self …

Inhalable CAR-T cell-derived exosomes as paclitaxel carriers for treating lung cancer

W Zheng, T Zhu, L Tang, Z Li, G Jiang… - Journal of Translational …, 2023 - Springer
Background Non-small cell lung cancer (NSCLC) is a worldwide health threat with high
annual morbidity and mortality. Chemotherapeutic drugs such as paclitaxel (PTX) have been …

Diagnosing Orthotopic Lung Tumor Using a NTR-Activatable Near-Infrared Fluorescent Probe by Tracheal Inhalation

J Yan, K Wang, L Gui, X Liu, Y Ji, J Lin, M Luo… - Analytical …, 2023 - ACS Publications
Nitroreductase (NTR) is an enzyme that is upregulated under tumor-depleted oxygen
conditions. The majority of studies have been conducted on NTR, but many existing …

Zerumbone-incorporated liquid crystalline nanoparticles inhibit proliferation and migration of non-small-cell lung cancer in vitro

B Manandhar, KR Paudel, DD Clarence… - Naunyn-Schmiedeberg's …, 2024 - Springer
Lung cancer is the second most prevalent type of cancer and is responsible for the highest
number of cancer-related deaths worldwide. Non-small-cell lung cancer (NSCLC) makes up …

Emerging applications and prospects of NFκB decoy oligodeoxynucleotides in managing respiratory diseases

JK Datsyuk, KR Paudel, R Rajput, S Kokkinis… - Chemico-biological …, 2023 - Elsevier
Chronic respiratory diseases like asthma and Chronic Obstructive Pulmonary Disease
(COPD) have been a burden to society for an extended period. Currently, there are only …

Inhalation drug delivery in combating pulmonary infections: Advances and challenges

P Kumbhar, J Kaur, G De Rubis, KR Paudel… - Journal of Drug Delivery …, 2023 - Elsevier
Pulmonary infections (PIs) are contributing as a significant cause of mortality across the
world. The clinical applications of a variety of therapeutics approved for PIs have been …

Nanoparticulate drugs and vaccines: breakthroughs and bottlenecks of repurposing in breast cancer

P Kumbhar, K Kole, V Khadake, P Marale… - Journal of Controlled …, 2022 - Elsevier
Breast cancer (BC) is a highly diagnosed and topmost cause of death in females worldwide.
Drug repurposing (DR) has shown great potential against BC by overcoming major …

Co-crystal nanoarchitectonics as an emerging strategy in attenuating cancer: Fundamentals and applications

P Kumbhar, K Kolekar, C Khot, S Dabhole… - Journal of Controlled …, 2023 - Elsevier
Cancer ranks as the second foremost cause of death in various corners of the globe. The
clinical uses of assorted anticancer therapeutics have been limited owing to the poor …