Suppressive Effects of N-Acetyl-d-Glucosamine on Rheumatoid Arthritis Mouse Models

K Azuma, T Osaki, T Wakuda, T Tsuka, T Imagawa… - Inflammation, 2012 - Springer
We examined effects of N-acetyl-d-glucosamine (GlcNAc) on rheumatoid arthritis (RA)
mouse models and effects of GlcNAc and glucosamine hydrochloride (GlcN) on several …

Recent aspects of the anti-inflammatory actions of glucosamine

I Nagaoka, M Igarashi, J Hua, Y Ju, S Yomogida… - Carbohydrate …, 2011 - Elsevier
Glucosamine, a naturally occurring amino monosaccharide, is present in the connective and
cartilage tissues as a component of glycosaminoglycans. Thus, glucosamine has been …

Application of glucosamine on human disease—osteoarthritis

H Nakamura - Carbohydrate Polymers, 2011 - Elsevier
Osteoarthritis (OA) is a disease that affects various joints in elderly population. Wear of
articular cartilage and syonovitis are characteristic feature of OA. Cartilage matrix is mainly …

Glucosamine use and risk of colorectal cancer: results from the Cancer Prevention Study II Nutrition Cohort

ED Kantor, CC Newton, EL Giovannucci… - Cancer Causes & …, 2018 - Springer
Purpose Use of glucosamine supplements has been associated with reduced risk of
colorectal cancer (CRC) in previous studies; however, information on this association …

Biological activities of glucosamine and its related substances

I Nagaoka, M Igarashi, K Sakamoto - Advances in food and nutrition …, 2012 - Elsevier
Glucosamine (GlcN) has been widely used to treat osteoarthritis (OA) in humans. We
revealed that among GlcN-derivatives (GlcN and N-acetyl-d-glucosamine) and uronic acids …

Glucosamine suppresses interleukin-8 production and ICAM-1 expression by TNF-α-stimulated human colonic epithelial HT-29 cells

S Yomogida, J Hua… - … journal of molecular …, 2008 - spandidos-publications.com
Intestinal epithelial cells play an important role in the mucosal immune reaction in
inflammatory bowel diseases via the production and expression of chemokines and …

The role of O-GlcNAcylation in bone metabolic diseases

Y Yang, X Zhou, HL Deng, L Chen, X Zhang… - Frontiers in …, 2024 - frontiersin.org
O-GlcNAcylation, as a post-translational modification, can modulate cellular activities such
as kinase activity, transcription-translation, protein degradation, and insulin signaling by …

Bioinformatics and systems biology approaches to identify molecular targeting mechanism influenced by COVID-19 on heart failure

K Yang, J Liu, Y Gong, Y Li, Q Liu - Frontiers in immunology, 2022 - frontiersin.org
Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) has emerged as a contemporary hazard to people. It has been …

Modulation of TNF-α-induced endothelial cell activation by glucosamine, a naturally occurring amino monosaccharide

Y Ju, J Hua, K Sakamoto… - … journal of molecular …, 2008 - spandidos-publications.com
Atherosclerosis is now considered a chronic inflammatory disease, and glucosamine has
the potential to exhibit an anti-inflammatory action. Thus, we investigated the effect of …

Glucosamine Downregulates the IL-1β-Induced Expression of Proinflammatory Cytokine Genes in Human Synovial MH7A Cells by O-GlcNAc Modification …

A Someya, T Ikegami, K Sakamoto, I Nagaoka - PloS one, 2016 - journals.plos.org
Osteoarthritis (OA) is one of the major joint diseases, and the synovial inflammation is
involved in the pathogenesis and progression of OA. Glucosamine (GlcN) is widely used as …