Chemoprevention strategies reduce malaria disease and death, but the efficacy of anti-
malarial drugs used for chemoprevention is perennially threatened by drug resistance. This …

Introduction Since the spread of chloroquine resistance in Plasmodium falciparum in the
1960s, recommendations have been made on how to respond to antimalarial resistance …

Artemisinin combination therapies are the first-line treatments for uncomplicated
Plasmodium falciparum malaria in most malaria-endemic countries. Recently, partial …

Mathematical models have been used to provide an explicit framework for understanding
malaria transmission dynamics in human population for over 100 years. With the disease …

Combination therapy for the treatment of visceral leishmaniasis has increasingly been
advocated as a way to increase treatment efficacy and tolerance, reduce treatment duration …

The emergence of resistance to former first-line antimalarial drugs has been an unmitigated
disaster. In recent years, artemisinin class drugs have become standard and they are …

Background Preventing the emergence of anti-malarial drug resistance is critical for the
success of current malaria elimination efforts. Prevention strategies have focused …

Background The increase in artemisinin resistance threatens malaria elimination in Asia by
the target date of 2030 and could derail control efforts in other endemic regions. This study …

Background. Artemisinin-based combination therapy (ACT) reduces the potential for malaria
transmission, compared with non-ACTs. It is unclear whether this effect differs between …

The effectiveness of artemisinin-based combination therapies (ACTs) to treat Plasmodium
falciparum malaria is threatened by resistance. The complex interplay between sources of …