The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor originally
isolated and characterized as the dioxin or xenobiotic receptor. With the discovery of …

Essential hypertension (HTN) is a disease where genetic and environmental factors interact
to produce a high prevalent set of almost indistinguishable phenotypes. The weak definition …

Backgrounds To study the effects of supplementation of a marine omega-3 poly-unsaturated
fatty acids (n3-PUFA) formulation (Omega3Q10) in older adults with hypertension and/or …

Objective: Hypertension and vitamin D deficiency are prevalent worldwide, especially in the
elderly. Considering the possibility of gene–environment contributions to disease …

Aim: CYP1A1 is a metabolizing enzyme and key polymorphisms in its gene may contribute
to the risk of ischemic stroke. This study aimed to investigate the association of the …

The present study investigated the role of echinocystic acid (EA) on the expression of
nuclear factor (NF)‑κB and cytochrome P450 1A1 (CYP1A1), and aortic morphology, in a rat …

Previous case-control studies on the relationship between the CYP4F2 gene rs2108622
polymorphism and hypertension have produced contrasting results. In this study, we aimed …

Objective Vitamin D deficiency is known as an important risk factor in pathogenesis of
atherosclerosis, which contributes to stroke development. Genetic variations including single …

Cytochrome P450 metabolism of arachidonic acid produces epoxyeicosatrienoates (EETs)
and hydroxyeicosatetraenoates (HETEs). Both classes of eicosanoids play important and …

Purpose Soluble epoxide hydrolase (sEH) and microsomal epoxide hydrolase (mEH) both
catalyze the metabolism of epoxyeicosatrienoic acids (EETs), lipid signaling molecules that …