Glioblastoma multiforme (GBM) is one of the worst brain tumors arising from glial cells,
causing many deaths annually. Surgery, chemotherapy, radiotherapy and immunotherapy …

RNA interference currently offers new opportunities for gene therapy by the specific
extinction of targeted gene (s) in cancer diseases. However, the main challenge for nucleic …

This review provides a perspective on porous silicon (pSi)–based nanomaterials including
nanoparticles, nanowires, and thin films, that are currently being used in advanced therapy …

Research in designing and engineering long-circulating nanoparticles, so-called
'stealth'nanoparticles, has been attracting increasing interest as a new platform for targeted …

The discovery of RNA interference has revitalized the long ongoing pursuit of gene therapy
for the treatment of diseases. Nevertheless, despite promising results from experimental …

In recent years, nucleic acid-based therapeutics have gained increasing importance as
novel treatment options for disease prevention and treatment. Synthetic messenger RNAs …

In 1998, the RNA interference discovery by Fire and Mello revolutionized the scientific and
therapeutic world. They showed that small double-stranded RNAs, the siRNAs, were …

With the increasing number of studies proposing new and optimal delivery strategies for the
efficacious silencing of gene-related diseases by the local administration of siRNAs, the …

RNA interference (RNAi) was intensively studied in the past decades due to its potential in
therapy of diseases. The target specificity and universal treatment spectrum endowed siRNA …

Over the past two decades, RNA interference has become an extensively studied
mechanism to silence gene and treat diseases including cancer. siRNA appears as a …