Purinergic receptors (Rs) of the ATP/ADP, UTP/UDP (P2X, P2Y) and adenosine (A1, A2A)-
sensitive classes broadly interfere with cognitive processes both under quasi normal and …

Epilepsy is one of the most common and disabling chronic neurological diseases affecting
people of all ages. Major challenges of epilepsy management include the persistently high …

Based on available evidence, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) is a neuroinvasive virus. According to the centers for disease control and prevention …

Epilepsy, characterized by recurrent spontaneous seizures, is a heterogeneous group of
brain diseases affecting over 70 million people worldwide. Major challenges in the …

Abstract P2X7R, which is a member of the purinergic P2 receptor family, is widely expressed
in many immune cells, such as macrophages, lymphocytes, monocytes, and neutrophils …

Introduction Astrocytes have previously been considered as cells supporting neuronal
functions, but they are now recognized as active players in maintaining central nervous …

P2X7 receptors (P2X7R), as a brain inflammation biomarker, play important roles in the
epileptogenic progress. Mounting evidence supports their activation in the brain during …

In clinical practice, depression and anxiety frequently coexist, and they are both comorbid
with somatic diseases. The P2X7R is an adenosine 5'-triphosphate (ATP)-gated non …

Abstract Extracellular adenosine 5′-triphosphate (ATP) is a vital signaling molecule
involved in various physiological processes within the body. In recent years, studies have …

Radioligands targeting microglia cells have been developed to identify and determine
neuroinflammation in the living brain. One recently discovered ligand is JNJ-64413739 that …