Obesity is a risk factor for cancer development and is associated with poor prognosis in
multiple tumor types. The positive energy balance linked with obesity induces a variety of …

Excess body weight is associated not only with an increased risk of type 2 diabetes and
cardiovascular disease (CVD) but also with various types of malignancies. Adiponectin, the …

Pathway analysis is often the first choice for studying the mechanisms underlying a
phenotype. However, conventional methods for pathway analysis do not take into account …

Resistin was originally described as an adipocyte-secreted peptide that induced insulin
resistance in rodents. Increasing evidence indicates its important regulatory roles in various …

Obesity is a leading modifiable risk factor for the development of several epithelial
malignancies. In addition to increasing risk, obesity also confers worse prognosis for many …

Metformin is widely used in the treatment of diabetes mellitus type 2 where it reduces insulin
resistance and diabetes-related morbidity and mortality. Population-based studies show that …

Recent studies have demonstrated that obesity is a significant risk factor for the development
of several malignancies, but the mechanisms underlying this relationship remain to be fully …

Interest in the biology of white adipose tissue (WAT) has increased dramatically since the
discovery of leptin in 1994. The identification of the product of the gene obese (ob) threw …

Background Breast cancer is the second most common cause of cancer-related death
among women. Advances in our understanding of the disease have translated into better …

Lipid droplet formation is a defining histological feature in clear-cell renal cell carcinoma
(ccRCC) but the underlying mechanisms and importance of this biological behaviour have …