Primary biliary cholangitis (PBC) is an autoimmune liver disease characterized by biliary
destruction, progressive cholestasis, and potentially liver cirrhosis. Patients develop a well …

Cholestatic liver disease denotes any situation associated with impaired bile flow
concomitant with a noxious bile acid accumulation in the liver and/or systemic circulation …

Peptide-major histocompatibility complex class II (pMHCII)-based nanomedicines displaying
tissue-specific autoantigenic epitopes can blunt specific autoimmune conditions by re …

The burgeoning field of innate immune training, also called trained immunity, has given
immunologists new insights into the role of innate responses in protection against infection …

Abstract Primary Biliary Cholangitis (PBC) is an uncommon, chronic, cholangiopathy of
autoimmune origin and unknown etiology characterized by positive anti-mitochondrial …

Primary biliary cholangitis (PBC) is a chronic, progressive cholestatic liver disease in which
the small intrahepatic bile ducts are destroyed by autoimmune reactions. Among …

Obesity has been implicated in the rise of autoimmunity in women. We report that obesity
induces a serum protein signature that is associated with T helper 1 (Th1), interleukin (IL) …

Cholangiocarcinoma (CCA) results from the malignant transformation of cholangiocytes.
Primary sclerosing cholangitis (PSC) and primary biliary cholangitis (PBC) are chronic …

The immune system responds differently in women and in men. Generally speaking, adult
females show stronger innate and adaptive immune responses than males. This results in …

Autoreactive B cells can promote autoimmunity through antigen presentation to autoreactive
T cells, production of autoantibodies, generation of cytokines promoting T cell activation and …