The role of Toll-like receptors and neuroinflammation in Parkinson's disease

A Heidari, N Yazdanpanah, N Rezaei - Journal of Neuroinflammation, 2022 - Springer
Background Parkinson's disease (PD) is the second most prevalent neurodegenerative
disorder, characterized by motor and non-motor symptoms, significantly affecting patients' …

Lipopolysaccharide-induced model of neuroinflammation: mechanisms of action, research application and future directions for its use

A Skrzypczak-Wiercioch, K Sałat - Molecules, 2022 - mdpi.com
Despite advances in antimicrobial and anti-inflammatory therapies, inflammation and its
consequences still remain a significant problem in medicine. Acute inflammatory responses …

Biodegradable Hollow‐Structured Nanozymes Modulate Phenotypic Polarization of Macrophages and Relieve Hypoxia for Treatment of Osteoarthritis

H Xiong, Y Zhao, Q Xu, X Xie, J Wu, B Hu, S Chen… - Small, 2022 - Wiley Online Library
Nanozymes are widely applied for treating various major diseases, including neurological
diseases and tumors. However, the biodegradability of nanozymes remains a great …

Modulation of the innate immune response by targeting toll-like receptors: a perspective on their agonists and antagonists

S Federico, L Pozzetti, A Papa, G Carullo… - Journal of Medicinal …, 2020 - ACS Publications
Toll-like receptors (TLRs) are a class of proteins that recognize pathogen-associated
molecular patterns (PAMPs) and damaged-associated molecular patterns (DAMPs), and …

Alzheimer's genes in microglia: a risk worth investigating

A Sudwarts, G Thinakaran - Molecular neurodegeneration, 2023 - Springer
Despite expressing many key risk genes, the role of microglia in late-onset Alzheimer's
disease pathophysiology is somewhat ambiguous, with various phenotypes reported to be …

(R)-Ketamine attenuates LPS-induced endotoxin-derived delirium through inhibition of neuroinflammation

J Zhang, L Ma, X Wan, J Shan, Y Qu, K Hashimoto - Psychopharmacology, 2021 - Springer
Rationale (R)-Ketamine produced beneficial effects in a variety of models of inflammatory
diseases, including low dose of bacterial lipopolysaccharide (LPS)(0.5–1.0 mg/kg)-induced …

The Role of Intestinal Microbiota and Diet as Modulating Factors in the Course of Alzheimer's and Parkinson's Diseases

W Czarnik, P Fularski, A Gajewska, P Jakubowska… - Nutrients, 2024 - mdpi.com
Many researchers propose manipulating microbiota to prevent and treat related diseases.
The brain–gut axis is an object that remains the target of modern research, and it is not …

Toll-like receptors and NLRP3 inflammasome-dependent pathways in Parkinson's disease: mechanisms and therapeutic implications

L Soraci, ME Gambuzza, L Biscetti, P Laganà… - Journal of …, 2023 - Springer
Parkinson's disease (PD) is a chronic progressive neurodegenerative disorder
characterized by motor and non-motor disturbances as a result of a complex and not fully …

Effects of 3.5 GHz radiofrequency radiation on ghrelin, nesfatin-1, and irisin level in diabetic and healthy brains

H Bektas, S Algul, F Altindag, K Yegin… - Journal of chemical …, 2022 - Elsevier
Diabetes, mobile phone use, and obesity have increased simultaneously in recent years.
The radiofrequency radiation (RFR) emitted from mobile phones is largely absorbed in the …

[HTML][HTML] Ketogenic diet alleviates cognitive dysfunction and neuroinflammation in APP/PS1 mice via the Nrf2/HO-1 and NF-κB signaling pathways

J Jiang, H Pan, F Shen, Y Tan… - Neural regeneration …, 2023 - journals.lww.com
Alzheimer's disease is a progressive neurological disorder characterized by cognitive
decline and chronic inflammation within the brain. The ketogenic diet, a widely recognized …