The role of Toll-like receptors and neuroinflammation in Parkinson's disease
Background Parkinson's disease (PD) is the second most prevalent neurodegenerative
disorder, characterized by motor and non-motor symptoms, significantly affecting patients' …
disorder, characterized by motor and non-motor symptoms, significantly affecting patients' …
Lipopolysaccharide-induced model of neuroinflammation: mechanisms of action, research application and future directions for its use
A Skrzypczak-Wiercioch, K Sałat - Molecules, 2022 - mdpi.com
Despite advances in antimicrobial and anti-inflammatory therapies, inflammation and its
consequences still remain a significant problem in medicine. Acute inflammatory responses …
consequences still remain a significant problem in medicine. Acute inflammatory responses …
Biodegradable Hollow‐Structured Nanozymes Modulate Phenotypic Polarization of Macrophages and Relieve Hypoxia for Treatment of Osteoarthritis
H Xiong, Y Zhao, Q Xu, X Xie, J Wu, B Hu, S Chen… - Small, 2022 - Wiley Online Library
Nanozymes are widely applied for treating various major diseases, including neurological
diseases and tumors. However, the biodegradability of nanozymes remains a great …
diseases and tumors. However, the biodegradability of nanozymes remains a great …
Modulation of the innate immune response by targeting toll-like receptors: a perspective on their agonists and antagonists
S Federico, L Pozzetti, A Papa, G Carullo… - Journal of Medicinal …, 2020 - ACS Publications
Toll-like receptors (TLRs) are a class of proteins that recognize pathogen-associated
molecular patterns (PAMPs) and damaged-associated molecular patterns (DAMPs), and …
molecular patterns (PAMPs) and damaged-associated molecular patterns (DAMPs), and …
Alzheimer's genes in microglia: a risk worth investigating
A Sudwarts, G Thinakaran - Molecular neurodegeneration, 2023 - Springer
Despite expressing many key risk genes, the role of microglia in late-onset Alzheimer's
disease pathophysiology is somewhat ambiguous, with various phenotypes reported to be …
disease pathophysiology is somewhat ambiguous, with various phenotypes reported to be …
(R)-Ketamine attenuates LPS-induced endotoxin-derived delirium through inhibition of neuroinflammation
J Zhang, L Ma, X Wan, J Shan, Y Qu, K Hashimoto - Psychopharmacology, 2021 - Springer
Rationale (R)-Ketamine produced beneficial effects in a variety of models of inflammatory
diseases, including low dose of bacterial lipopolysaccharide (LPS)(0.5–1.0 mg/kg)-induced …
diseases, including low dose of bacterial lipopolysaccharide (LPS)(0.5–1.0 mg/kg)-induced …
The Role of Intestinal Microbiota and Diet as Modulating Factors in the Course of Alzheimer's and Parkinson's Diseases
W Czarnik, P Fularski, A Gajewska, P Jakubowska… - Nutrients, 2024 - mdpi.com
Many researchers propose manipulating microbiota to prevent and treat related diseases.
The brain–gut axis is an object that remains the target of modern research, and it is not …
The brain–gut axis is an object that remains the target of modern research, and it is not …
Toll-like receptors and NLRP3 inflammasome-dependent pathways in Parkinson's disease: mechanisms and therapeutic implications
L Soraci, ME Gambuzza, L Biscetti, P Laganà… - Journal of …, 2023 - Springer
Parkinson's disease (PD) is a chronic progressive neurodegenerative disorder
characterized by motor and non-motor disturbances as a result of a complex and not fully …
characterized by motor and non-motor disturbances as a result of a complex and not fully …
Effects of 3.5 GHz radiofrequency radiation on ghrelin, nesfatin-1, and irisin level in diabetic and healthy brains
Diabetes, mobile phone use, and obesity have increased simultaneously in recent years.
The radiofrequency radiation (RFR) emitted from mobile phones is largely absorbed in the …
The radiofrequency radiation (RFR) emitted from mobile phones is largely absorbed in the …
[HTML][HTML] Ketogenic diet alleviates cognitive dysfunction and neuroinflammation in APP/PS1 mice via the Nrf2/HO-1 and NF-κB signaling pathways
J Jiang, H Pan, F Shen, Y Tan… - Neural regeneration …, 2023 - journals.lww.com
Alzheimer's disease is a progressive neurological disorder characterized by cognitive
decline and chronic inflammation within the brain. The ketogenic diet, a widely recognized …
decline and chronic inflammation within the brain. The ketogenic diet, a widely recognized …