Clinical translation of advanced colonic drug delivery technologies
Targeted drug delivery to the colon offers a myriad of benefits, including treatment of local
diseases, direct access to unique therapeutic targets and the potential for increasing …
diseases, direct access to unique therapeutic targets and the potential for increasing …
Oral delivery of natural active small molecules by polymeric nanoparticles for the treatment of inflammatory bowel diseases
M Zu, Y Ma, B Cannup, D Xie, Y Jung, J Zhang… - Advanced Drug Delivery …, 2021 - Elsevier
The incidence of inflammatory bowel disease (IBD) is rapidly rising throughout the world.
Although tremendous efforts have been made, limited therapeutics are available for IBD …
Although tremendous efforts have been made, limited therapeutics are available for IBD …
[HTML][HTML] Gut microbiota-derived inosine from dietary barley leaf supplementation attenuates colitis through PPARγ signaling activation
D Li, Y Feng, M Tian, J Ji, X Hu, F Chen - Microbiome, 2021 - Springer
Background Ulcerative colitis is a type of chronic inflammatory bowel disease closely
associated with gut microbiota dysbiosis and intestinal homeostasis dysregulation. Barley …
associated with gut microbiota dysbiosis and intestinal homeostasis dysregulation. Barley …
Oxyberberine, a novel gut microbiota-mediated metabolite of berberine, possesses superior anti-colitis effect: impact on intestinal epithelial barrier, gut microbiota …
C Li, G Ai, Y Wang, Q Lu, C Luo, L Tan, G Lin… - Pharmacological …, 2020 - Elsevier
Abstract Berberine (BBR), a naturally-occurring isoquinoline alkaloid isolated from several
Chinese herbal medicines, has been widely used for the treatment of dysentery and colitis …
Chinese herbal medicines, has been widely used for the treatment of dysentery and colitis …
[HTML][HTML] Interactions between intestinal microbiota and host immune response in inflammatory bowel disease
M Zhang, K Sun, Y Wu, Y Yang, P Tso… - Frontiers in …, 2017 - frontiersin.org
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal
tract. Although the etiology and pathogenesis of IBD remain unclear, both genetic …
tract. Although the etiology and pathogenesis of IBD remain unclear, both genetic …
3D printed medicines: A new branch of digital healthcare
Abstract Three-dimensional printing (3DP) is a highly disruptive technology with the
potential to change the way pharmaceuticals are designed, prescribed and produced …
potential to change the way pharmaceuticals are designed, prescribed and produced …
Dihydroquercetin supplement alleviates colonic inflammation potentially through improved gut microbiota community in mice
F Wan, H Han, R Zhong, M Wang, S Tang, S Zhang… - Food & Function, 2021 - pubs.rsc.org
The purpose of the current study was to investigate the effect of dietary dihydroquercetin
(DHQ) supplementation on dextran sodium sulfate (DSS)-induced colitis in mice. Mice were …
(DHQ) supplementation on dextran sodium sulfate (DSS)-induced colitis in mice. Mice were …
Probiotics importance and their immunomodulatory properties
Mammalian intestine contains a large diversity of commensal microbiota, which is far more
than the number of host cells. Probiotics play an insecure and protective role against the …
than the number of host cells. Probiotics play an insecure and protective role against the …
Thyme (Thymus vulgaris L.) polyphenols ameliorate DSS-induced ulcerative colitis of mice by mitigating intestinal barrier damage, regulating gut microbiota, and …
Z Zhou, W He, H Tian, P Zhan, J Liu - Food & function, 2023 - pubs.rsc.org
Thyme (Thymus vulgaris L.) is an important medicinal and edible homologous plant, and the
composition and bioactivity of its polyphenol extracts have attracted widespread attention …
composition and bioactivity of its polyphenol extracts have attracted widespread attention …
Functions and signaling pathways of amino acids in intestinal inflammation
F He, C Wu, P Li, N Li, D Zhang, Q Zhu… - BioMed research …, 2018 - Wiley Online Library
Intestine is always exposed to external environment and intestinal microorganism; thus it is
more sensitive to dysfunction and dysbiosis, leading to intestinal inflammation, such as …
more sensitive to dysfunction and dysbiosis, leading to intestinal inflammation, such as …