Duchenne muscular dystrophy (DMD) is a progressive muscle-wasting disorder. It is caused
by loss-of-function mutations in the dystrophin gene. Currently, there is no cure. A highly …

Duchenne muscular dystrophy (DMD) is an X-linked recessive disease resulting in the loss
of dystrophin, a key cytoskeletal protein in the dystrophin-glycoprotein complex. Dystrophin …

Muscular Dystrophy, convened a Working Group meeting on July 2014, in Bethesda, MD, to
explore clinical and research questions related to cardiac disease in patients with DMD. As …

Duchenne muscular dystrophy (DMD) is a devastating disease affecting approximately 1 in
every 3,500 male births worldwide. Multiple mutations in the dystrophin gene have been …

Sarcoglycanopathies are a group of autosomal recessive muscle-wasting disorders caused
by genetic defects in one of four cell membrane glycoproteins, α-, β-, γ-or δ-sarcoglycan …

The mechanism of force reduction is not completely understood in Duchenne muscular
dystrophy (DMD), a dystrophin‐deficient lethal disease. Nitric oxide regulates muscle force …

Dystrophin deficiency leads to lethal dilated Duchenne cardiomyopathy. A promising
therapy is to deliver a highly abbreviated microdystrophin gene to the heart using adeno …

Duchenne muscular dystrophy (DMD) is a lethal muscle disease caused by dystrophin
deficiency. In normal muscle, dystrophin helps maintain sarcolemmal stability. Dystrophin …

Duchenne muscular dystrophy (DMD) is a dystrophin-deficient lethal muscle disease. To
date, the catastrophic muscle wasting phenotype has only been seen in dystrophin-deficient …

Loss of dystrophin leads to Duchenne muscular dystrophy (DMD). A pathogenic feature of
DMD is the significant elevation of cytosolic calcium. Supraphysiological calcium triggers …