Antibody–drug conjugates for cancer
CH Chau, PS Steeg, WD Figg - The Lancet, 2019 - thelancet.com
Antibody–drug conjugates (ADCs) are immunoconjugates comprised of a monoclonal
antibody tethered to a cytotoxic drug (known as the payload) via a chemical linker. The ADC …
antibody tethered to a cytotoxic drug (known as the payload) via a chemical linker. The ADC …
[HTML][HTML] Diagnosis and treatment of VOD/SOS after allogeneic hematopoietic stem cell transplantation
F Bonifazi, F Barbato, F Ravaioli, M Sessa… - Frontiers in …, 2020 - frontiersin.org
Hepatic veno-occlusive disease (VOD) or sinusoidal obstruction syndrome (SOS) is a rare
complication characterized by hepatomegaly, right-upper quadrant pain, jaundice, and …
complication characterized by hepatomegaly, right-upper quadrant pain, jaundice, and …
[HTML][HTML] Systematic preclinical evaluation of CD33-directed chimeric antigen receptor T cell immunotherapy for acute myeloid leukemia defines optimized construct …
Background Successful development of chimeric antigen receptor (CAR) T cell
immunotherapy for children and adults with relapsed/refractory acute myeloid leukemia …
immunotherapy for children and adults with relapsed/refractory acute myeloid leukemia …
[HTML][HTML] Results of salvage therapy with mini-hyper-CVD and inotuzumab ozogamicin with or without blinatumomab in pre-B acute lymphoblastic leukemia
Background Historically, adults with relapsed-refractory acute lymphoblastic leukemia (ALL)
experienced poor outcomes with intensive chemotherapy. This mature analysis explores the …
experienced poor outcomes with intensive chemotherapy. This mature analysis explores the …
Modified diagnostic criteria, grading classification and newly elucidated pathophysiology of hepatic SOS/VOD after haematopoietic cell transplantation
MS Cairo, KR Cooke, HM Lazarus… - British journal of …, 2020 - Wiley Online Library
Sinusoidal obstruction syndrome (SOS), previously known as hepatic veno‐occlusive
disease (VOD), remains a multi‐organ system complication following haematopoietic cell …
disease (VOD), remains a multi‐organ system complication following haematopoietic cell …
[HTML][HTML] A rodent model of human-dose-equivalent 5-fluorouracil: toxicity in the liver, kidneys, and lungs
MC da Silva, LC Fabiano, KC da Costa Salomão… - Antioxidants, 2023 - mdpi.com
5-Fluorouracil (5-FU) is a chemotherapy drug widely used to treat a range of cancer types,
despite the recurrence of adverse reactions. Therefore, information on its side effects when …
despite the recurrence of adverse reactions. Therefore, information on its side effects when …
Acute kidney injury and CKD associated with hematopoietic stem cell transplantation
ADM Renaghan, EA Jaimes, J Malyszko… - Clinical Journal of the …, 2020 - journals.lww.com
Hematopoietic stem cell transplantation is a life-saving therapy for many patients with
cancer, as well as patients with some nonmalignant hematologic disorders, such as aplastic …
cancer, as well as patients with some nonmalignant hematologic disorders, such as aplastic …
Defibrotide plus best standard of care compared with best standard of care alone for the prevention of sinusoidal obstruction syndrome (HARMONY): a randomised …
SA Grupp, S Corbacioglu, HJ Kang… - The Lancet …, 2023 - thelancet.com
Background Sinusoidal obstruction syndrome, also known as veno-occlusive disease, is a
potentially life-threatening complication of haematopoietic stem-cell transplantation (HSCT) …
potentially life-threatening complication of haematopoietic stem-cell transplantation (HSCT) …
Advances in the diagnosis and treatment of disseminated intravascular coagulation in haematological malignancies
T Ikezoe - International journal of hematology, 2021 - Springer
Haematological malignancies, including acute leukaemia and non-Hodgkin lymphoma, are
one of the underlying diseases that frequently cause disseminated intravascular coagulation …
one of the underlying diseases that frequently cause disseminated intravascular coagulation …
[HTML][HTML] Treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia in adults
K Saleh, A Fernandez, F Pasquier - Cancers, 2022 - mdpi.com
Simple Summary Outcome of patients with Philadelphia-chromosome positive acute
lymphoblastic leukemia (Ph+ ALL) dramatically improved during the past 20 years with the …
lymphoblastic leukemia (Ph+ ALL) dramatically improved during the past 20 years with the …