Pro-inflammatory signalling PRRopels cisplatin-induced toxicity
IK Domingo, A Latif, AP Bhavsar - International journal of molecular …, 2022 - mdpi.com
Cisplatin is a platinum-based chemotherapeutic that has long since been effective against a
variety of solid-cancers, substantially improving the five-year survival rates for cancer …
variety of solid-cancers, substantially improving the five-year survival rates for cancer …
Nickel‐Catalyzed Enantioconvergent Carboxylation Enabled by a Chiral 2, 2′‐Bipyridine Ligand
L Wang, T Li, S Perveen, S Zhang, X Wang… - Angewandte …, 2022 - Wiley Online Library
In contrast to previous approaches to chiral α‐aryl carboxylic acids that based on reactions
using hazardous gases, pressurized setup and mostly noble metal catalysts, in this work, a …
using hazardous gases, pressurized setup and mostly noble metal catalysts, in this work, a …
[HTML][HTML] Design, synthesis and anticancer evaluation of novel Se-NSAID hybrid molecules: Identification of a Se-indomethacin analog as a potential therapeutic for …
A total of twenty-five novel carboxylic acid, methylester, methylamide or cyano nonsteroidal
anti-inflammatory drug (NSAID) derivatives incorporating Se in the chemical form of …
anti-inflammatory drug (NSAID) derivatives incorporating Se in the chemical form of …
Selenization of Small Molecule Drugs: A New Player on the Board
There is an urgent need to develop safer and more effective modalities for the treatment of a
wide range of pathologies due to the increasing rates of drug resistance, undesired side …
wide range of pathologies due to the increasing rates of drug resistance, undesired side …
[HTML][HTML] Multi-action platinum (IV) prodrugs conjugated with COX-inhibiting NSAIDs
X Liu, D Wenisch, P Dahlke, PM Jordan… - European Journal of …, 2023 - Elsevier
In the last decades, inflammation has been recognized as being closely connected to
cancer, and joint strategies encompassing chemotherapeutic and anti-inflammatory agents …
cancer, and joint strategies encompassing chemotherapeutic and anti-inflammatory agents …
Structural and Biological Properties of Heteroligand Copper Complexes with Diethylnicotinamide and Various Fenamates: Preparation, Structure, Spectral Properties …
M Piroš, M Schoeller, K Koňariková, J Valentová… - Inorganics, 2023 - mdpi.com
Herein, we discuss the synthesis, structural and spectroscopic characterization, and
biological activity of five heteroligand copper (II) complexes with diethylnicotinamide and …
biological activity of five heteroligand copper (II) complexes with diethylnicotinamide and …
Anti-inflammatory efficacy and relevant SAR investigations of novel chiral pyrazolo isoquinoline derivatives: Design, synthesis, in-vitro, in-vivo, and computational …
M Akhtar, J Niu, Y Zhu, Z Luo, T Tian, Y Dong… - European Journal of …, 2023 - Elsevier
Isoquinoline alkaloids are a rich source of multimodal agents with distinctive structural
specificity and various pharmacological activities. In the present report, we propose a …
specificity and various pharmacological activities. In the present report, we propose a …
Synthesis, cytotoxicity, antioxidant activity and molecular modeling of new NSAIDs-EBS derivatives
M Zhong, Y Lu, S Li, X Li, Z Liu, X He… - European Journal of …, 2023 - Elsevier
Two series of NSAIDs-EBS derivatives (5a-j and 9a-i) based on the hybridization of
nonsteroidal anti-inflammatory drugs (NSAIDs) skeleton and Ebselen moiety were …
nonsteroidal anti-inflammatory drugs (NSAIDs) skeleton and Ebselen moiety were …
Versatile platinum (iv) prodrugs of naproxen and acemetacin as chemo-anti-inflammatory agents
Simple Summary Traditional intravenous platinum (II) chemotherapy drugs such as cisplatin,
oxaliplatin and carboplatin are highly effective in treating multiple cancer types …
oxaliplatin and carboplatin are highly effective in treating multiple cancer types …
Stimuli-responsive prodrug of non-steroidal anti-inflammatory drug diclofenac: self-immolative drug release with turn-on near-infrared fluorescence
A Sufian, D Bhattacherjee, P Barman… - Chemical …, 2022 - pubs.rsc.org
Reactive oxygen species (ROS)-responsive near infrared (NIR) fluorogenic prodrug DCI-
ROS is developed for the self-immolative release of diclofenac (DCF) with turn-on …
ROS is developed for the self-immolative release of diclofenac (DCF) with turn-on …