The role of Andrographolide in the prevention and treatment of liver diseases
X Qin, X Wang, M Tian, Z Dong, J Wang, C Wang… - Phytomedicine, 2023 - Elsevier
Background The presence or absence of damage to the liver organ is crucial to a person's
health. Nutritional disorders, alcohol consumption, and drug abuse are the main causes of …
health. Nutritional disorders, alcohol consumption, and drug abuse are the main causes of …
Ginsenoside Rd Inhibited Ferroptosis to Alleviate CCl4-Induced Acute Liver Injury in Mice via cGAS/STING Pathway
Y Li, P Yu, W Fu, S Wang, W Zhao, Y Ma… - The American Journal …, 2023 - World Scientific
Carbon tetrachloride (CCl4)-induced lipid peroxidation associated with hepatic oxidative
stress and cell death is an important mechanism of acute liver injury (ALI). Ginsenoside Rd …
stress and cell death is an important mechanism of acute liver injury (ALI). Ginsenoside Rd …
[HTML][HTML] The janus face of serotonin: Regenerative promoter and chronic liver disease aggravator
B Mao, S Liu, S Zhu, F Wu, W Yuan, Y Yan, B Wang - Heliyon, 2024 - cell.com
The progression of liver diseases, from viral hepatitis and fatty liver disease to cirrhosis and
hepatocellular carcinoma (HCC), is the most representative series of pathological events in …
hepatocellular carcinoma (HCC), is the most representative series of pathological events in …
Myocardial ischemia-reperfusion injury is probably due to the excessive production of mitochondrial ROS caused by the activation of 5-HT degradation system …
J Jin, F Xu, Y Zhang, J Guan, J Fu - Molecular Immunology, 2023 - Elsevier
Aim Previously, we revealed a crucial role of 5-HT degradation system (5DS), consisting of 5-
HT2A receptor (5-HT2AR), 5-HT synthases and monoamine oxidase A (MAO-A), in ischemia …
HT2A receptor (5-HT2AR), 5-HT synthases and monoamine oxidase A (MAO-A), in ischemia …
[HTML][HTML] The effect of Abrus cantoniensis Hance on liver damage in mice
L Li, Y Tu, X Dai, S Xiao, Z Tang, Y Wu, D Fouad… - Ecotoxicology and …, 2023 - Elsevier
The liver is a well-known organ contributing to digestion, hemostasis and detoxification,
while liver injury is a world-widely distributed health problem with limited treatment choices …
while liver injury is a world-widely distributed health problem with limited treatment choices …
[HTML][HTML] Mechanisms of 5-HT receptor antagonists in the regulation of fibrosis in a 3D human liver spheroid model
S Redenšek Trampuž, S van Riet, Å Nordling… - Scientific Reports, 2024 - nature.com
Non-alcoholic steatohepatitis (NASH) is a major health problem leading to liver fibrosis and
hepatocellular carcinoma, among other diseases, and for which there is still no approved …
hepatocellular carcinoma, among other diseases, and for which there is still no approved …
Nephrotoxicity induced by cisplatin is primarily due to the activation of the 5-hydroxytryptamine degradation system in proximal renal tubules
J Guan, X Tong, Y Zhang, F Xu, Y Zhang… - Chemico-Biological …, 2021 - Elsevier
As a widely used anticancer drug in the clinic, cisplatin has obvious side effects, especially
nephrotoxicity. Previous studies have suggested that the accumulation of intracellular …
nephrotoxicity. Previous studies have suggested that the accumulation of intracellular …
Profile of 5-HT2A receptor involved in signaling cascades associated to intracellular inflammation and apoptosis in hepatocytes and its role in carbon tetrachloride …
Y Zhang, Y Wang, K Zhang, X Liang, J Guan, J Jin… - Cellular …, 2023 - Elsevier
Previously, we found that the 5-HT 2A receptor plays a key role in cell injury. However, the
mechanism by which the 5-HT 2A receptor mediates intracellular processes remains …
mechanism by which the 5-HT 2A receptor mediates intracellular processes remains …
[HTML][HTML] Study on the mechanism of acute liver injury protection in Rhubarb anthraquinone by metabolomics based on UPLC-Q-TOF-MS
X Gong, F Zhang, Y Li, C Peng - Frontiers in Pharmacology, 2023 - frontiersin.org
As a traditional Chinese medicine, rhubarb has been used in a variety of liver diseases and
it is widely used in clinic to prevent and treat acute liver injury. Anthraquinone, as the main …
it is widely used in clinic to prevent and treat acute liver injury. Anthraquinone, as the main …
Renal ischemia/reperfusion injury in rats is probably due to the activation of the 5-HT degradation system in proximal renal tubular epithelial cells
J Jin, F Xu, Y Zhang, J Guan, X Liang, Y Zhang, A Yuan… - Life Sciences, 2021 - Elsevier
Aims To explore the relationship between renal ischemia/reperfusion injury (RIRI) and the
activation of the renal 5-HT degradation system, including 5-HT 2A receptor (5-HT 2A R), 5 …
activation of the renal 5-HT degradation system, including 5-HT 2A receptor (5-HT 2A R), 5 …