Ventriculitis or post-neurosurgical meningitis or healthcare-associated ventriculitis and
meningitis (VM) is a severe infection that complicates central nervous system operations or …

Introduction The choice of best therapeutic strategy for difficult-to-treat resistance (DTR)
Gram-negative infections currently represents an unmet clinical need. Areas covered This …

Importance Meropenem is a widely prescribed β-lactam antibiotic. Meropenem exhibits
maximum pharmacodynamic efficacy when given by continuous infusion to deliver constant …

Background Effective antimicrobial treatment is key to reduce mortality associated with
bacterial sepsis in patients on intensive care units (ICUs). Dose adjustments are often …

Although available data are still limited, real-world evidence regarding mainly ceftolozane-
tazobactam and ceftazidime-avibactam could support the administration of novel beta …

Background The prolonged β-lactam antibiotics infusion has been an attractive strategy in
severe infections, because it provides a more stable free drug concentration and a longer …

Importance There is uncertainty about whether prolonged infusions of β-lactam antibiotics
improve clinically important outcomes in critically ill adults with sepsis or septic shock …

Critically ill patients admitted to intensive care unit (ICU) with severe infections, or those who
develop nosocomial infections, have poor outcomes with substantial morbidity and mortality …

Despite their limitations, the pharmacokinetics (PK) and pharmacodynamics (PD) indices
form the basis for our current understanding regarding antibiotic development, selection …

Background Optimal β-lactam dosing for the treatment of Gram-negative bacteria
bloodstream infections (GNB-BSIs) remains a debated issue. Herein, the efficacy and safety …