Tau is a microtubule-associated protein that plays a major role in Alzheimer's disease (AD)
and other tauopathies. Recent reports indicate that, in the presence of crowding agents, tau …

Proteinaceous aggregates are major hallmarks of several neurodegenerative diseases.
Aggregates of post-translationally modified transactive response (TAR)-DNA binding protein …

Subcellular compartmentalization contributes to the organization of a plethora of molecular
events occurring within cells. This can be achieved in membraneless organelles generated …

Sumoylation is an essential post-translational modification that has evolved to regulate
intricate networks within emerging complexities of eukaryotic cells. Thousands of target …

Membraneless organelles (MLOs) are phase-separated liquid compartments providing
spatiotemporal control of biomolecules and metabolism within cells. While MLOs exhibit …

Transition of soluble proteins into insoluble amyloid fibrils is driven by self-propagating short
sequence stretches. However, accurate prediction of aggregation determinants remains …

Liquid–liquid phase separation has drawn attention as many neurodegeneration or cancer-
associated proteins are able to form liquid membraneless compartments (condensates) by …

The intracellular environment is partitioned into functionally distinct compartments
containing specific sets of molecules and reactions. Biomolecular condensates, also …

Increasing experiments suggest that amyloid peptides can undergo liquid–liquid phase
separation (LLPS) before the formation of amyloid fibrils. However, the exact role of LLPS in …

Liquid–liquid phase separation (LLPS) is an emerging phenomenon in cell physiology and
diseases. The weak multivalent interaction prerequisite for LLPS is believed to be facilitated …