Biological liquid–liquid phase separation has gained considerable attention in recent years
as a driving force for the assembly of subcellular compartments termed membraneless …

Simple Summary It is essential for cellular homeostasis that biomolecules, such as DNA,
proteins, and lipids, function properly. Disturbance of redox homeostasis produces aberrant …

The majority of our genome is composed of repeated DNA sequences that assemble into
heterochromatin, a highly compacted structure that constrains their mutational potential …

Biomolecular condensates are important contributors to the internal organization of the cell
material. While initially described as liquid-like droplets, the term biomolecular condensates …

Structural conversion of cellular prion protein (PrPC) into scrapie PrP (PrPSc) and
subsequent aggregation are key events associated with the onset of transmissible …

ABSTRACT Dishvelled-2 (Dvl2) is an essential component of Wnt pathway, which controls
several cell fate decisions during development, such as proliferation, survival and …

Biomolecular condensates are reversible compartments that form through a process called
phase separation. Post-translational modifications like ADP-ribosylation can nucleate the …

Cellular organelles that lack a surrounding lipid bilayer, such as the nucleolus and stress
granule, represent a newly recognized, general paradigm of cellular organization. The …

Key early features of amyotrophic lateral sclerosis (ALS) are denervation of neuromuscular
junctions and axonal degeneration. Motor neuron homeostasis relies on local translation …

Liquid-liquid phase separation (LLPS) of proteins mediates the assembly of biomolecular
condensates involved in physiological and pathological processes. Identifying the …