Hyperosmotic phase separation: Condensates beyond inclusions, granules and organelles
AP Jalihal, A Schmidt, G Gao, SR Little… - Journal of Biological …, 2021 - ASBMB
Biological liquid–liquid phase separation has gained considerable attention in recent years
as a driving force for the assembly of subcellular compartments termed membraneless …
as a driving force for the assembly of subcellular compartments termed membraneless …
Cell death via lipid peroxidation and protein aggregation diseases
K Iuchi, T Takai, H Hisatomi - Biology, 2021 - mdpi.com
Simple Summary It is essential for cellular homeostasis that biomolecules, such as DNA,
proteins, and lipids, function properly. Disturbance of redox homeostasis produces aberrant …
proteins, and lipids, function properly. Disturbance of redox homeostasis produces aberrant …
A change in biophysical properties accompanies heterochromatin formation in mouse embryos
M Guthmann, C Qian, I Gialdini, T Nakatani… - Genes & …, 2023 - genesdev.cshlp.org
The majority of our genome is composed of repeated DNA sequences that assemble into
heterochromatin, a highly compacted structure that constrains their mutational potential …
heterochromatin, a highly compacted structure that constrains their mutational potential …
Time-dependent material properties of aging biomolecular condensates from different viscoelasticity measurements in molecular dynamics simulations
AR Tejedor, R Collepardo-Guevara… - The Journal of …, 2023 - ACS Publications
Biomolecular condensates are important contributors to the internal organization of the cell
material. While initially described as liquid-like droplets, the term biomolecular condensates …
material. While initially described as liquid-like droplets, the term biomolecular condensates …
Liquid‐liquid phase separation and fibrillation of the prion protein modulated by a high‐affinity DNA aptamer
CO Matos, YM Passos, MJ do Amaral… - The FASEB …, 2020 - Wiley Online Library
Structural conversion of cellular prion protein (PrPC) into scrapie PrP (PrPSc) and
subsequent aggregation are key events associated with the onset of transmissible …
subsequent aggregation are key events associated with the onset of transmissible …
Ubiquitin-assisted phase separation of dishevelled-2 promotes Wnt signalling
V Vamadevan, N Chaudhary… - Journal of Cell …, 2022 - journals.biologists.com
ABSTRACT Dishvelled-2 (Dvl2) is an essential component of Wnt pathway, which controls
several cell fate decisions during development, such as proliferation, survival and …
several cell fate decisions during development, such as proliferation, survival and …
Regulation of biomolecular condensates by Poly (ADP-ribose)
Biomolecular condensates are reversible compartments that form through a process called
phase separation. Post-translational modifications like ADP-ribosylation can nucleate the …
phase separation. Post-translational modifications like ADP-ribosylation can nucleate the …
A guide to regulation of the formation of biomolecular condensates
A Bratek‐Skicki, R Pancsa, B Meszaros… - The FEBS …, 2020 - Wiley Online Library
Cellular organelles that lack a surrounding lipid bilayer, such as the nucleolus and stress
granule, represent a newly recognized, general paradigm of cellular organization. The …
granule, represent a newly recognized, general paradigm of cellular organization. The …
Lost in local translation: TDP-43 and FUS in axonal/neuromuscular junction maintenance and dysregulation in amyotrophic lateral sclerosis
D Piol, T Robberechts, S Da Cruz - Neuron, 2023 - cell.com
Key early features of amyotrophic lateral sclerosis (ALS) are denervation of neuromuscular
junctions and axonal degeneration. Motor neuron homeostasis relies on local translation …
junctions and axonal degeneration. Motor neuron homeostasis relies on local translation …
Prediction and characterization of liquid-liquid phase separation of minimalistic peptides
Liquid-liquid phase separation (LLPS) of proteins mediates the assembly of biomolecular
condensates involved in physiological and pathological processes. Identifying the …
condensates involved in physiological and pathological processes. Identifying the …