Cells have evolved molecular chaperones that modulate phase separation and misfolding of
amyloidogenic proteins to prevent neurodegenerative diseases. Protein disulfide isomerase …

Nature utilizes both order and disorder (or controlled disorder) to achieve exceptional
materials properties and functions, while synthetic supramolecular materials mostly exploit …

Abstract Changes in amyloid-beta-oligomer (AβΟ) peptides levels are considered one of the
major neuropathologic biomarkers for Alzheimer's Disease (AD). AβΟ levels can be …

It is increasingly recognized that local protein synthesis (LPS) contributes to fundamental
aspects of axon biology, in both developing and mature neurons. Mutations in RNA-binding …

Three common Apolipoprotein E isoforms, ApoE2, ApoE3, and ApoE4, are key regulators of
lipid homeostasis, among other functions. Apolipoprotein E can interact with amyloid …

Membrane-free intracellular biocondensates are enclosures of proteins and nucleic acids
that form by phase separation. Extensive ensembles of nuclear" membraneless organelles" …

The complex coacervation of proteins with other macromolecules has applications in protein
encapsulation and delivery and for determining the function of cellular coacervates …

Cell fate transition is a fascinating process involving complex dynamics of three-dimensional
(3D) chromatin organization and phase separation, which play an essential role in cell fate …

The prion protein is a multifunctional protein that exists in at least two different folding states.
It is subject to diverse proteolytic processing steps that lead to prion protein fragments some …

Cells need to organise and regulate their biochemical processes both in space and time in
order to adapt to their surrounding environment. Spatial organisation of cellular components …