Hepatic cirrhosis and hepatocellular carcinoma (HCC) are the most common causes of
death in patients with chronic liver disease. Chronic liver injury of virtually any etiology …

The IκB kinase (IKK) complex is the signal integration hub for NF‐κB activation. Composed
of two serine‐threonine kinases (IKK α and IKK β) and the regulatory subunit NEMO (also …

We show that the antidiabetic drug metformin inhibits the expression of genes coding for
multiple inflammatory cytokines seen during cellular senescence. Conditioned medium (CM) …

Nuclear factor-κB (NF-κB) consists of a family of transcription factors that play critical roles in
inflammation, immunity, cell proliferation, differentiation, and survival. Inducible NF-κB …

The innate immune system constitutes the first line of defense against invading microbial
pathogens and relies on a large family of pattern recognition receptors (PRRs), which detect …

Different animal and human studies from last two decades in the case of Parkinson's
disease (PD) have concentrated on oxidative stress due to increased inflammation and …

The interleukin-1 (IL-1) family of cytokines comprises 11 proteins (IL-1F1 to IL-1F11)
encoded by 11 distinct genes in humans and mice. IL-1–type cytokines are major mediators …

Radiation therapy (RT) provides therapeutic benefits for patients with glioblastoma (GBM),
but inevitably induces poorly understood global changes in GBM and its microenvironment …

Mangifera indica (family Anacardiaceae), commonly known as mango, is a
pharmacologically, ethnomedically, and phytochemically diverse plant. Various parts of M …

The transcription factor NF-κB has served as a standard for inducible transcription factors for
more than 20 years. The numerous stimuli that activate NF-κB, and the large number of …