NF-κB (nuclear factor-κB) is a collective name for inducible dimeric transcription factors
composed of members of the Rel family of DNA-binding proteins that recognize a common …

The transcription factor NF-κB has been the focus of intense investigation for nearly two
decades. Over this period, considerable progress has been made in determining the …

Oxidative stress and inflammation are proved to be critical for the pathogenesis of diabetes
mellitus. Berberine (BBR) is a natural compound isolated from plants such as Coptis …

A single mouse click on the topic tumor necrosis factor (TNF) in PubMed reveals about 50
000 articles providing one or the other information about this pleiotropic cytokine or its …

The regulation of the transcription factor NF-κB activity occurs at several levels including
controlled cytoplasmic-nuclear shuttling and modulation of its transcriptional activity. A …

In both type 1 and type 2 diabetes, the late diabetic complications in nerve, vascular
endothelium, and kidney arise from chronic elevations of glucose and possibly other …

A substantial knowledge on the pathogenesis of diabetes mellitus (DM) by oxidative stress
and inflammation is available. Berberine is a biologically active botanical that can combat …

Nuclear factor-κB (NF-κB) has been widely implicated in the development and progression
of cancer. In colorectal cancer (CRC), NF-κB has a key role in cancer-related processes …

TRAF6 is a signal transducer that activates IκB kinase (IKK) and Jun amino-terminal kinase
(JNK) in response to pro-inflammatory mediators such as interleukin-1 (IL-1) and …

Apoptosis is a physiological cell suicide program that is critical for the development and
maintenance of healthy tissues. Dysregulation of cell death pathways occur in cancer …