All eukaryotic cells have an extensive membranous labyrinth network of branching tubules
and flattened sacs called the endoplasmic reticulum (ER). Approximately one-third of all …

TRAF6 is a signal transducer in the NF-κB pathway that activates IκB kinase (IKK) in
response to proinflammatory cytokines. We have purified a heterodimeric protein complex …

Tumor necrosis factor α (TNF-α) binding to the TNF receptor (TNFR) potentially initiates
apoptosis and activates the transcription factor nuclear factor kappa B (NF-κB), which …

1, 25-Dihydroxyvitamin D (1, 25 (OH) 2 D 3) is known to suppress NF-κB activity, but the
underlying mechanism remains poorly understood. Here we show that the vitamin D …

Cardiovascular diseases are the most common cause of mortality worldwide. Oxidative
stress and inflammation are pathophysiological processes involved in the development of …

Activation of the nuclear transcription factor NF-κB by inflammatory cytokines requires the
successive action of NF-κB-inducing kinase (NIK) and an IκB-kinase (IKK) complex …

NF-κB comprises a family of cellular transcription factors that are involved in the inducible
expression of a variety of cellular genes that regulate the inflammatory response,. NF-κB is …

Members of the nuclear factor kappa B (NF-κB) family of dimeric transcription factors (TFs)
regulate expression of a large number of genes involved in immune responses …

Glycogen synthase kinase-3β (GSK3β) is a fascinating enzyme with an astoundingly diverse
number of actions in intracellular signaling systems. GSK3β activity is regulated by serine …

Gene expression profiling has revealed that diffuse large B cell lymphoma (DLBCL) consists
of at least two distinct diseases. Patients with one DLBCL subtype, termed activated B cell …