The mechanisms of cell proliferation and transformation are intrinsically linked to the
process of apoptosis: the default of proliferating cells is to die unless specific survival signals …

Apoptosis is implicated in the generation and resolution of inflammation in response to
bacterial pathogens. All bacterial pathogens produce lipoproteins (BLPs), which trigger the …

Abstract Interleukin-1 (IL-1) is a proinflammatory cytokine that has several effects in the
inflammation process. When it binds to its cell-surface receptor, IL-1 initiates a signalling …

NF-κB transcription factors have key roles in inflammation, immune response, oncogenesis
and protection against apoptosis,. In most cells, these factors are kept inactive in the …

IL-1 is a proinflammatory cytokine that signals through a receptor complex of two different
transmembrane chains to generate multiple cellular responses, including activation of the …

Copyright 2000 Academic PressNF-κB is a heterodimeric transcription factor that plays a key
role in inflammatory and immune responses. In non-stimulated cells, NF-κB dimers are …

Extracellular stimuli elicit a variety of responses, such as cell proliferation and differentiation,
through the cellular signalling system. Binding of growth factors to the respective receptor …

Although the molecular mechanisms of TNF signaling have been largely elucidated, the
principle that regulates the balance of life and death is still unknown. We report here that the …

Inflammation is viewed as one of the major causes for the development of different diseases
like cancer, cardiovascular disease, diabetes, obesity, osteoporosis, rheumatoid arthritis …

The inhibitory effects of vitamin D on colitis have been previously documented. Global
vitamin D receptor (VDR) deletion exaggerates colitis, but the relative anticolitic contribution …