Ubiquitin-mediated proteolysis has a central role in controlling the intracellular levels of
several important regulatory molecules such as cyclins, CKIs, p53, and IκBα. Many diverse …

Innate immunity represents the first line of defence against invading pathogens. It consists of
an initial inflammatory response that recruits white blood cells to the site of infection in an …

The nuclear factor-κB (NF-κB) signalling pathway regulates immune responses and is
implicated in the pathogenesis of many inflammatory diseases. Given the well established …

▪ Abstract Four members of the tumor necrosis factor (TNF) ligand family, TNF-α, LT-α, LT-β,
and LIGHT, interact with four receptors of the TNF/nerve growth factor family, the p55 TNF …

The effects of pathogenic organisms on host intestinal epithelial cells are vast. Innumerable
signalling pathways are triggered leading ultimately to drastic changes in physiological …

Reactive oxygen species (ROS) are generated at sites of inflammation and injury, and at low
levels, ROS can function as signaling molecules participating as signaling intermediates in …

NF-κB plays a critical role in the transcriptional regulation of proinflammatory gene
expression in various cells. Cytokine-mediated activation of NF-κB requires activation of …

The diverse cellular and biological functions of the nuclear factor kappa B (NF-κB) pathway,
together with the catastrophic consequences of its aberrant regulation, demand specific and …

The inducible transcription factor NF-κB plays a central role in the regulation of many
immune and inflammatory responses. Advances in our knowledge of the signaling …

IL-1β is a prototypical proinflammatory cytokine that plays a central role in the intestinal
inflammation amplification cascade. Recent studies have indicated that a TNF-α-and IFN-γ …