Nuclear factor (NF)-κB is a family of seven structurally related transcription factors that play a
central role in cardiovascular growth, stress response, and inflammation by controlling gene …

Background & Aims: Transcription factors of the nuclear factor κB (NF-κB) family play an
important role in the regulation of genes involved in inflammation. In inflammatory bowel …

Nuclear factor kappa B (NF-κB) transcription factors regulate several important physiological
processes, including inflammation and immune responses, cell growth, apoptosis, and the …

The IκB kinase (IKK) complex is composed of three subunits, IKKα, IKKβ, and IKKγ (NEMO).
While IKKα and IKKβ are highly similar catalytic subunits, both capable of IκB …

IKKβ-dependent NF-κB activation plays a key role in innate immunity and inflammation, and
inhibition of IKKβ has been considered as a likely anti-inflammatory therapy. Surprisingly …

Pro-inflammatory cytokines activate the transcription factor NF-κB by stimulating the activity
of a protein kinase that phosphorylates IκB, an inhibitor of NF-κB,,,,, at sites that trigger its …

Molecular Control of Immune/Inflammatory Responses: Interactions Between Nuclear Factor-κB
and Steroid Receptor-Signaling Pathways | Endocrine Reviews | Oxford Academic Skip to …

Nuclear factor-κB (NF-κB) is a ubiquitous transcription factor that governs the expression of
genes encoding cytokines, chemokines, growth factors, cell adhesion molecules, and some …

Recent investigations have elucidated the cytokine-induced NF-κB activation pathway. IκB
kinase (IKK) phosphorylates inhibitors of NF-κB (IκBs). The phosphorylation targets them for …

Transcription factors of the NF-κB family regulate hundreds of genes in the context of
multiple important physiological and pathological processes. NF-κB activation depends on …