We have characterized a flat cellular variant of HTLV-1 Tax-transformed rat fibroblasts, 5R,
which is unresponsive to all tested NF-κB activating stimuli, and we report here its genetic …

The nuclear factor‐κB (NF‐κB) signaling pathway is a busy ground for the action of the
ubiquitin–proteasome system; many of the signaling steps are coordinated by protein …

Toll-like receptors (TLRs) are key components of the innate immune system, functioning as
pattern recognition receptors that recognise a wide range of microbial pathogens. TLRs …

Nuclear factor-κB (NFκB) is a transcription factor with a pivotal role in inducing genes
involved in physiological processes as well as in the response to injury and infection. A …

IκB [inhibitor of nuclear factor κB (NF-κB)] kinase (IKK) phosphorylates IκB inhibitory
proteins, causing their degradation and activation of transcription factor NF-κB, a master …

Regulation of NF-κB transactivation function is controlled at several levels, including
interactions with coactivator proteins. Here we show that the transactivation function of NF …

The inhibitor of kappa B kinase (IKK) family consists of IKKα, IKKβ, and the IKK-related
kinases TBK1 and IKKε. These kinases are considered master regulators of inflammation …

Epidemiological studies suggest that low vitamin D levels may increase the risk or severity of
respiratory viral infections. In this study, we examined the effect of vitamin D on respiratory …

Tumor necrosis factor (TNF)-α, a key mediator of intestinal inflammation, causes an increase
in intestinal epithelial tight junction (TJ) permeability by activating myosin light chain kinase …

Background & Aims: The transcription factor nuclear factor–κB (NF-κB) plays a central role in
regulating immune and inflammatory responses. Because butyrate deficiency has been …